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As of now, it's slated for Oct. 15 at the Adrienne Arsht Center for the Performing Arts in Miami.
Depending on what happens this upcoming week, viewers could potentially see the debate take to Zoom, a digital video conferencing service, which might prove more feasible, Mashable reported.
"Hopefully, the president feels up to it and, you know, they can work this out remotely," McConnell said in a radio interview Friday.
“I don’t want to get ahead of the White House, but it’s entirely possible to have a debate virtually in two weeks,” Mosbacher told BBC Radio 4’s Today show.
Even before the president's positive test, calls for a remote debate were rising following the first debate on Tuesday.
On Wednesday, the Commission on Presidential Debates announced it was looking at changes to the format "to ensure a more orderly discussion of the issues."
This wouldn't be the first Zoom debate.
In May, candidates for office in New York's U.S. Congressional District 14 held their first entirely virtual debate ahead of the state's June primaries.
U.S. House of Representatives Congressional districts have been using Zoom as a debate platform since March.
And next week, Connecticut's 5th Congressional District is hosting its own.