Image source: Getty Images.
Shares of Merrimack Pharmaceuticals, Inc. (NASDAQ: MACK)a cancer-focused biopharmaceutical company, fell 17.8% in October, according to data from S&P Global Market Intelligence. A staff reduction increased concerns that its recently launched cancer therapy might disappoint investors.
With 426 full-time employees at the beginning of the year, Merrimack's staff wasn't enormous to begin with. News it would cut its headcount by 22% almost a year following Onivyde'sFDA approval doesn't inspire confidence in its commercial launch, nor Merrimack's ability to advance a bustling clinical-stage pipeline. Including the immediate resignation of CEO Robert Mulroy with the restructuring announcement is downright troubling.
The company's only commercial-stage drug, Onivyde, for treatment of pancreatic cancer, is essentially a longer-lasting version ofPfizer's Camptostar, a drug the FDA approved 20 years ago. Shire(NASDAQ: SHPG) inherited responsibility for commercializing Onivyde outside the U.S. and Taiwan from Baxalta, leaving Merrimack to support its U.S. commercial launch.
So far, the U.S. launch isn't going so well. First-half product revenue of just $22.82 million is far below the company's operating costs of $114.94 million during the period. Tack on another $29.73 million spent servicing long-term debts during the first half, and it's easy to see why a staff cut was necessary.
Merrimack's working capital fell from $97.65 million at the beginning of the year to just $28.15 million at the end of June.The company expects the staff reduction will eliminate over $200 million in costs over the next two years, but it probably won't be sufficient to avoid raising more capital in the near future.
With a bit of luck, though, Merrimack might not need to raise very much. OnivydeU.S. sales were expected to peak around $400 million per year ahead of the drug's launch. It significantly increased overall survival by two months versus the standard of care in second-line pancreatic cancer.That might not seem like much, but there hasn't been a major improvement for pancreatic cancer treatment in decades.
Shire announced an EU marketing approval for Onivyde to treat pancreatic cancer last month as well. Merrimack is entitled to a tiered double-digit royalty percentage on sales throughout the territory that could reach the low 20s. Investors will want to keep an eye on the European launch, and Merrimack's efforts to expand Onivyde's label to the first-line setting. Success here could bring the company to sustainable cash flows while it develops four additional clinical-stage candidates in its pipeline.
10 stocks we like better than Merrimack Pharmaceuticals When investing geniuses David and Tom Gardner have a stock tip, it can pay to listen. After all, the newsletter they have run for over a decade, Motley Fool Stock Advisor, has tripled the market.*
David and Tom just revealed what they believe are the ten best stocks for investors to buy right now and Merrimack Pharmaceuticals wasn't one of them! That's right -- they think these 10 stocks are even better buys.
Click here to learn about these picks!
*Stock Advisor returns as of November 7, 2016
Cory Renauer has no position in any stocks mentioned. The Motley Fool has no position in any of the stocks mentioned. Try any of our Foolish newsletter services free for 30 days. We Fools may not all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors. The Motley Fool has a disclosure policy.