Ford,Isis Pharmaceuticals, Seadrill, Cempra and Breitburn are big market movers

Stocks that moved substantially or traded heavily Monday on the New York Stock Exchange and the Nasdaq Stock Market:

NYSE

Ford Motor Co., down 60 cents to $14.76

The automobile company reported a 1 percent boost in U.S. sales in December but total vehicle sales for 2014 remained flat.

Seadrill Ltd., down $1.20 to $10.81

The offshore drilling contractor and its industry peers saw their stocks decline as the price of crude oil extends its slide.

Protalix BioTherapeutics Inc., up 30 cents to $2.17

The biotechnology company announced a strategy change, focusing on prioritizing drug candidates with a clear competitive advantage.

National Bank of Greece, down 18 cents to $1.66

The bank's stock suffered on continued concerns that upcoming elections in Greece could result in changes to a bailout agreement.

Nasdaq

Isis Pharmaceuticals Inc., up $6.60 to $68.17

Johnson & Johnson will pay the pharmaceutical company up to $835 million as part of a licensing deal for three potential drugs.

Cempra Inc., up $1.66 to $24.55

The company's oral version of an antibiotic met key goals in a late-stage clinical trial, moving it closer to FDA approval.

Breitburn Energy Partners LP, down 81 cents to $6.82

The energy producer cut shareholder payouts and capital spending as the price of crude oil tumbles.

Threshold Pharmaceuticals Inc., up 25 cents to $3.68

The biotechnology company reported positive preliminary data from a midstage clinical trial of a potential cancer treatment.