Exelixis, Inc. Grows Revenue, Eyes Treating More Patients

Sales of Exelixis' (NASDAQ: EXEL) kidney cancer drug Cabometyx continued to grow at a torrid pace in the second quarter, allowing the company to post another profitable quarter.

Exelixis results: The raw numbers


Q2 2017

Q2 2016

Year-Over-Year Change


$99 million

$36 million


Income from operations

$27 million

($25 million)


Earnings per share




What happened with Exelixis this quarter?

  • Most of the second quarter's revenue came from the $80.9 million in sales of Cabometyx, which was 30% higher than in the first quarter of the year. Exelixis thinks it's capturing about 35% of new patients in second-line or later treatment for kidney cancer, so there's room for additional growth.
  • Thyroid cancer drug Cometriq, which has the same active ingredient as Cabometyx, contributed another $7.1 million. The rest of the revenue came from partner collaborations.
  • The Cabosun clinical trial data, testing Cabometyx as first-line therapy for patients with advanced kidney cancer, was confirmed.
  • Exelixis paid off its remaining debt of $124 million, and is now debt-free. 
  • The biotech settled its dispute with Genentech over how expenses from their Cotellic collaboration should be shared since the drug is prescribed in combination with Zelboraf, which is wholly owned by Genentech.
  • Exelixis and partner Bristol-Myers Squibb (NYSE: BMY) started a phase 3 trial called CheckMate 9ER, testing Cabometyx with two of Bristol's immunotherapies, Yervoy and Opdivo, in patients with kidney cancer.
  • The company is also testing Cabometyx with Genentech's immunotherapy atezolizumab although that trial is at an earlier stage -- phase 1b.

What management had to say 

With two drugs on the market and essentially no pipeline to support future growth once Cabometyx and Cotellic hit peak sales, Exelixis plans to restock its pipeline through licensing or acquisition deals, starting with early-stage compounds, as Michael Morrissey, Exelixis' president and CEO, explained:

(Cabo is short for cabozantinib, the generic name for Cabometyx/Cometriq. I-O is short for immuno-oncology.)

The other way to restock the pipeline is to develop the drugs internally as it did with its currently marketed drugs. Peter Lamb, Exelixis' chief scientific officer, commented on the plan:

Looking forward

While Exelixis works to maximize sales of Cabometyx in second-line kidney cancer, there's potential for even larger sales increases if the drug can get approved for use in additional settings.

Exelixis plans to submit the Cabosun data to the Food and Drug Administration this quarter, setting up a potential expanded approval into first-line kidney cancer next year. Investors will get to look at the data at the European Society for Medical Oncology meeting next month.

Cabometyx is also in a phase 3 trial, called Celestial, in liver cancer, which should read out interim data before the end of the year. If the data is positive, Exelixis thinks it'll be able to submit an application to the FDA in the first quarter of next year. Otherwise, it'll have one more shot at showing Cabometyx can help liver cancer patients when Celestial concludes in 2018.

10 stocks we like better than ExelixisWhen investing geniuses David and Tom Gardner have a stock tip, it can pay to listen. After all, the newsletter they have run for over a decade, Motley Fool Stock Advisor, has tripled the market.*

David and Tom just revealed what they believe are the 10 best stocks for investors to buy right now... and Exelixis wasn't one of them! That's right -- they think these 10 stocks are even better buys.

Click here to learn about these picks!

*Stock Advisor returns as of August 1, 2017

Brian Orelli has no position in any stocks mentioned. The Motley Fool owns shares of and recommends Exelixis. The Motley Fool has a disclosure policy.