Delta has reduced flights between New York and Ghana's capital of Accra by 18 percent, citing weaker passenger demand.
Some African airlines have suspended service to Accra since the outbreak of Ebola in other West African countries.
Delta spokesman Anthony Black said Tuesday that the airline reduced flights between New York's John F. Kennedy International Airport and Accra throughout November, cutting about one flight per week. It now has 18 round-trip flights per month, down from 22 in November 2013. Black cited passenger demand but did not elaborate.
The Ebola epidemic has been centered in Sierra Leone, Guinea and Liberia. British Airways and Air France have suspended flights to those countries, which are separated from Ghana by the Ivory Coast.
Delta suspended service to Liberia in August, calling it a response to weak demand. The Atlanta-based airline's other destinations in Africa include Dakar, Senegal; Lagos, Nigeria; and Johannesburg, South Africa.