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"Just got a phone call that my name is trending," she wrote in the social media post. "And being trolled for some awful FAKE thing. It’s NOT TRUE. Haven't been raided, or arrested. Just sanitizing and self distancing with the rest of the world. Stay safe everybody."
Rumors circulated Tuesday alleging Winfrey was arrested after her Florida home had been raided in connection to a sex trafficking ring.
Other Hollywood big-names, such as filmmaker Ava Duvernay, soon came to her defense.
Page Six reported the fake news stemmed from an online message board for teens and young adults.
As of Wednesday morning, "Oprah" was still trending on Twitter, along with #OprahWinfrey, #opraharrested and "Leave Oprah."