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Shire plc Shire Plc : Director/Pdmr Shareholding -3-

TIDMSHP TIDMSHP

Director/PDMR Shareholding

December 20, 2017

- Shire plc (LSE: SHP, NASDAQ: SHPG)

Notification of transactions by persons discharging managerial

responsibilities

Details of the person discharging managerial responsibilities

1. ("PDMR") / person closely associated with them ("PCA")

a) Name Susan Kilsby

2. Reason for the notification

a) Position / status Chairman - PDMR

Initial notification /

b) amendment Initial notification

Details of the issuer, emission allowance participant,

3. auction platform, auctioneer or auction monitor

a) Name Shire plc

b) LEI 54930005LQRLI2UXRQ59

Details of the transaction(s): section to be repeated

for (i) each type of instrument; (ii) each type of

transaction; (iii) each date; and (iv) each place

4. where transactions have been conducted

Description of the

financial instrument,

a) type of instrument Shire plc American Depositary Shares ("ADSs")

Identification code ISIN: US82481R1068

Acquisition of ADSs, being the part of Ms. Kilsby's

Nature of the total fees that are paid in ADSs for the period of

b) transaction service from October 1 to December 31, 2017.

c) Price(s) and volume(s) Price(s) Volume(s)

$155.9200 178

d) Aggregated information N/A (single transaction)

- Aggregated volume

- Price

e) Date of the transaction December 19, 2017

f) Place of the EDGX

transaction

Details of the person discharging managerial responsibilities

1. ("PDMR") / person closely associated with them ("PCA")

a) Name William Burns

2. Reason for the notification

a) Position / status Senior Independent Director - PDMR

Initial notification /

b) amendment Initial notification

Details of the issuer, emission allowance participant,

3. auction platform, auctioneer or auction monitor

a) Name Shire plc

b) LEI 54930005LQRLI2UXRQ59

Details of the transaction(s): section to be repeated

for (i) each type of instrument; (ii) each type of

transaction; (iii) each date; and (iv) each place

4. where transactions have been conducted

Description of the

financial instrument, type Shire plc Ordinary Shares of 5 pence each ("Ordinary

a) of instrument Shares")

Identification code ISIN: JE00B2QKY057

Acquisition of Ordinary Shares, being the part of

Mr. Burns' total fees that are paid in Ordinary Shares

for the period of service from October 1 to December

b) Nature of the transaction 31, 2017.

c) Price(s) and volume(s) Price(s) Volume(s)

See appendix below

Aggregated information

- Aggregated volume

d) - Price Weighted average price Volume

GBP37.8950 180

e) Date of the transaction December 19, 2017

f) Place of the transaction XLON / BATE / CHIX / TRQX

Details of the person discharging managerial responsibilities

1. ("PDMR") / person closely associated with them ("PCA")

a) Name Dominic Blakemore

2. Reason for the notification

a) Position / status Non-Executive Director - PDMR

Initial notification /

b) amendment Initial notification

Details of the issuer, emission allowance participant,

3. auction platform, auctioneer or auction monitor

a) Name Shire plc

b) LEI 54930005LQRLI2UXRQ59

Details of the transaction(s): section to be repeated

for (i) each type of instrument; (ii) each type of

transaction; (iii) each date; and (iv) each place

4. where transactions have been conducted

Description of the

financial instrument, type Shire plc Ordinary Shares of 5 pence each ("Ordinary

a) of instrument Shares")

Identification code ISIN: JE00B2QKY057

Acquisition of Ordinary Shares, being the part of

Mr. Blakemore's total fees that are paid in Ordinary

Shares for the period of service from October 1 to

b) Nature of the transaction December 31, 2017.

c) Price(s) and volume(s) Price(s) Volume(s)

See appendix below

Aggregated information

- Aggregated volume

d) - Price Weighted average price Volume

GBP37.8950 165

e) Date of the transaction December 19, 2017

f) Place of the transaction XLON / BATE / CHIX / TRQX

Details of the person discharging managerial responsibilities

1. ("PDMR") / person closely associated with them ("PCA")

a) Name Olivier Bohuon

2. Reason for the notification

a) Position / status Non-Executive Director - PDMR

Initial notification /

b) amendment Initial notification

Details of the issuer, emission allowance participant,

3. auction platform, auctioneer or auction monitor

a) Name Shire plc

b) LEI 54930005LQRLI2UXRQ59

Details of the transaction(s): section to be repeated

for (i) each type of instrument; (ii) each type of

transaction; (iii) each date; and (iv) each place

4. where transactions have been conducted

Description of the

financial instrument, type Shire plc Ordinary Shares of 5 pence each ("Ordinary

a) of instrument Shares")

Identification code ISIN: JE00B2QKY057

Acquisition of Ordinary Shares, being the part of

Mr. Bohuon's total fees that are paid in Ordinary

Shares for the period of service from October 1 to

b) Nature of the transaction December 31, 2017.

c) Price(s) and volume(s) Price(s) Volume(s)

See appendix below

Aggregated information

- Aggregated volume

d) - Price Weighted average price Volume

GBP37.8950 161

e) Date of the transaction December 19, 2017

f) Place of the transaction XLON / BATE / CHIX / TRQX

Details of the person discharging managerial responsibilities

1. ("PDMR") / person closely associated with them ("PCA")

a) Name Ian Clark

2. Reason for the notification

a) Position / status Non-Executive Director - PDMR

Initial notification /

b) amendment Initial notification

Details of the issuer, emission allowance participant,

3. auction platform, auctioneer or auction monitor

a) Name Shire plc

b) LEI 54930005LQRLI2UXRQ59

Details of the transaction(s): section to be repeated

for (i) each type of instrument; (ii) each type of

transaction; (iii) each date; and (iv) each place

4. where transactions have been conducted

Description of the

financial instrument,

a) type of instrument Shire plc American Depositary Shares ("ADSs")

Identification code ISIN: US82481R1068

Acquisition of ADSs, being the part of Mr. Clark's

Nature of the total fees that are paid in ADSs for the period of

b) transaction service from October 1 to December 31, 2017.

c) Price(s) and volume(s) Price(s) Volume(s)

$155.9200 67

d) Aggregated information N/A (single transaction)

- Aggregated volume

- Price

e) Date of the transaction December 19, 2017

f) Place of the EDGX

transaction

Details of the person discharging managerial responsibilities

1. ("PDMR") / person closely associated with them ("PCA")

a) Name Gail Fosler

2. Reason for the notification

a) Position / status Non-Executive Director - PDMR

Initial notification /

b) amendment Initial notification

Details of the issuer, emission allowance participant,

3. auction platform, auctioneer or auction monitor

a) Name Shire plc

b) LEI 54930005LQRLI2UXRQ59

Details of the transaction(s): section to be repeated

for (i) each type of instrument; (ii) each type of

transaction; (iii) each date; and (iv) each place

4. where transactions have been conducted

Description of the

financial instrument,

a) type of instrument Shire plc American Depositary Shares ("ADSs")

Identification code ISIN: US82481R1068

Acquisition of ADSs, being the part of Ms. Fosler's

Nature of the total fees that are paid in ADSs for the period of

b) transaction service from October 1 to December 31, 2017.

c) Price(s) and volume(s) Price(s) Volume(s)

$155.9200 48

d) Aggregated information N/A (single transaction)

- Aggregated volume

- Price

e) Date of the transaction December 19, 2017

f) Place of the EDGX

transaction

Details of the person discharging managerial responsibilities

1. ("PDMR") / person closely associated with them ("PCA")

a) Name Steven Gillis

2. Reason for the notification

a) Position / status Non-Executive Director - PDMR

Initial notification /

b) amendment Initial notification

Details of the issuer, emission allowance participant,

3. auction platform, auctioneer or auction monitor

a) Name Shire plc

b) LEI 54930005LQRLI2UXRQ59

Details of the transaction(s): section to be repeated

for (i) each type of instrument; (ii) each type of

transaction; (iii) each date; and (iv) each place

4. where transactions have been conducted

Description of the

financial instrument,

a) type of instrument Shire plc American Depositary Shares ("ADSs")

Identification code ISIN: US82481R1068

Acquisition of ADSs, being the part of Dr. Gillis'

Nature of the total fees that are paid in ADSs for the period of

b) transaction service from October 1 to December 31, 2017.

c) Price(s) and volume(s) Price(s) Volume(s)

$155.9200 59

d) Aggregated information N/A (single transaction)

- Aggregated volume

- Price

e) Date of the transaction December 19, 2017

f) Place of the EDGX

transaction

Details of the person discharging managerial responsibilities

1. ("PDMR") / person closely associated with them ("PCA")

a) Name David Ginsburg

2. Reason for the notification

a) Position / status Non-Executive Director - PDMR

Initial notification /

b) amendment Initial notification

Details of the issuer, emission allowance participant,

3. auction platform, auctioneer or auction monitor

a) Name Shire plc

b) LEI 54930005LQRLI2UXRQ59

Details of the transaction(s): section to be repeated

for (i) each type of instrument; (ii) each type of

transaction; (iii) each date; and (iv) each place

4. where transactions have been conducted

Description of the

financial instrument,

a) type of instrument Shire plc American Depositary Shares ("ADSs")

Identification code ISIN: US82481R1068

Acquisition of ADSs, being the part of Dr. Ginsburg's

Nature of the total fees that are paid in ADSs for the period of

b) transaction service from October 1 to December 31, 2017.

c) Price(s) and volume(s) Price(s) Volume(s)

$155.9200 50

d) Aggregated information N/A (single transaction)

- Aggregated volume

- Price

e) Date of the transaction December 19, 2017

f) Place of the EDGX

transaction

Details of the person discharging managerial responsibilities

1. ("PDMR") / person closely associated with them ("PCA")

a) Name Sara Mathew

2. Reason for the notification

a) Position / status Non-Executive Director - PDMR

Initial notification /

b) amendment Initial notification

Details of the issuer, emission allowance participant,

3. auction platform, auctioneer or auction monitor

a) Name Shire plc

b) LEI 54930005LQRLI2UXRQ59

Details of the transaction(s): section to be repeated

for (i) each type of instrument; (ii) each type of

transaction; (iii) each date; and (iv) each place

4. where transactions have been conducted

Description of the

financial instrument,

a) type of instrument Shire plc American Depositary Shares ("ADSs")

Identification code ISIN: US82481R1068

Acquisition of ADSs, being the part of Ms. Mathew's

Nature of the total fees that are paid in ADSs for the period of

b) transaction service from October 1 to December 31, 2017.

c) Price(s) and volume(s) Price(s) Volume(s)

$155.9200 56

d) Aggregated information N/A (single transaction)

- Aggregated volume

- Price

e) Date of the transaction December 19, 2017

f) Place of the EDGX

transaction

Details of the person discharging managerial responsibilities

1. ("PDMR") / person closely associated with them ("PCA")

a) Name Anne Minto

2. Reason for the notification

a) Position / status Non-Executive Director - PDMR

Initial notification /

b) amendment Initial notification

Details of the issuer, emission allowance participant,

3. auction platform, auctioneer or auction monitor

a) Name Shire plc

b) LEI 54930005LQRLI2UXRQ59

Details of the transaction(s): section to be repeated

for (i) each type of instrument; (ii) each type of

transaction; (iii) each date; and (iv) each place

4. where transactions have been conducted

Description of the

financial instrument, type Shire plc Ordinary Shares of 5 pence each ("Ordinary

a) of instrument Shares")

Identification code ISIN: JE00B2QKY057

Acquisition of Ordinary Shares, being the part of

Ms. Minto's total fees that are paid in Ordinary Shares

for the period of service from October 1 to December

b) Nature of the transaction 31, 2017.

c) Price(s) and volume(s) Price(s) Volume(s)

See appendix below

Aggregated information

- Aggregated volume

d) - Price Weighted average price Volume

GBP37.8950 182

e) Date of the transaction December 19, 2017

f) Place of the transaction XLON / BATE / CHIX / TRQX

Details of the person discharging managerial responsibilities

1. ("PDMR") / person closely associated with them ("PCA")

a) Name Albert Stroucken

2. Reason for the notification

a) Position / status Non-Executive Director - PDMR

Initial notification /

b) amendment Initial notification

Details of the issuer, emission allowance participant,

3. auction platform, auctioneer or auction monitor

a) Name Shire plc

b) LEI 54930005LQRLI2UXRQ59

Details of the transaction(s): section to be repeated

for (i) each type of instrument; (ii) each type of

transaction; (iii) each date; and (iv) each place

4. where transactions have been conducted

Description of the

financial instrument,

a) type of instrument Shire plc American Depositary Shares ("ADSs")

Identification code ISIN: US82481R1068

Acquisition of ADSs, being the part of Mr. Stroucken's

Nature of the total fees that are paid in ADSs for the period of

b) transaction service from October 1 to December 31, 2017.

c) Price(s) and volume(s) Price(s) Volume(s)

$155.9200 64

d) Aggregated information N/A (single transaction)

- Aggregated volume

- Price

e) Date of the transaction December 19, 2017

f) Place of the EDGX

transaction

Appendix: individual / aggregated transaction details for PDMRs

Shire plc Ordinary Shares of 5 pence each

Place of the transaction Price(s) Volume(s)

XLON GBP37.8850 15

XLON GBP37.8850 43

XLON GBP37.8850 71

XLON GBP37.9000 194

XLON GBP37.9000 265

BATE GBP37.8850 36

CHIX GBP37.8850 9

CHIX GBP37.8850 37

TRQX GBP37.8850 1

TRQX GBP37.8850 17

Place of the transaction Weighted average price Aggregated volume

XLON GBP37.8967 588

BATE GBP37.8850 36

CHIX GBP37.8850 46

TRQX GBP37.8850 18

Total GBP37.8950 688

Oliver Strawbridge

Senior Assistant Company Secretary

For further information please contact:

Investor Relations

Ian Karp ikarp@shire.com +1 781 482 9018

Robert Coates rcoates@shire.com +44 1256 894874

Media

Lisa Adler lisa.adler@shire.com +1 617 588 8607

Katie Joyce kjoyce@shire.com +1 781 482 2779

NOTES TO EDITORS

About Shire

Shire is the leading global biotechnology company focused on serving

people with rare diseases. We strive to develop best-in-class products,

many of which are available in more than 100 countries, across core

therapeutic areas including Hematology, Immunology, Neuroscience,

Ophthalmics, Lysosomal Storage Disorders, Gastrointestinal / Internal

Medicine / Endocrine and Hereditary Angioedema; and a growing franchise

in Oncology.

Our employees come to work every day with a shared mission: to develop

and deliver breakthrough therapies for the hundreds of millions of

people in the world affected by rare diseases and other high-need

conditions, and who lack effective therapies to live their lives to the

fullest.

www.shire.com

This announcement is distributed by Nasdaq Corporate Solutions on behalf

of Nasdaq Corporate Solutions clients.

The issuer of this announcement warrants that they are solely

responsible for the content, accuracy and originality of the information

contained therein.

Source: Shire plc via Globenewswire

(END) Dow Jones Newswires

December 20, 2017 07:45 ET (12:45 GMT)