Hertz Global Holdings Inc said Chief Executive Mark Frissora has stepped down for personal reasons.
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The car rental company's board appointed Hertz Equipment Rental Corp's head, Brian MacDonald, as interim CEO.
The company said it had started a search process for a replacement for Frissora, who also held the position of chairman.
Hertz also appointed independent lead director Linda Fayne Levinson as independent non-executive chair of the board.