spyre therapeutics inc - SYRE

SYRE

Close Chg Chg %
76.44 -1.36 -1.78%

Closed Market

75.08

-1.36 (1.78%)

Volume: 981.53K

Last Updated:

Jun 10, 2026, 4:00 PM EDT

Company Overview: spyre therapeutics inc - SYRE

SYRE Key Data

Open

$77.18

Day Range

74.79 - 79.52

52 Week Range

13.93 - 79.54

Market Cap

$6.64B

Shares Outstanding

86.84M

Public Float

77.42M

Beta

3.06

Rev. Per Employee

N/A

P/E Ratio

N/A

EPS

-$2.36

Yield

0.00%

Dividend

N/A

EX-DIVIDEND DATE

SHORT INTEREST

N/A

AVERAGE VOLUME

1.06M

 

SYRE Performance

1 Week
 
1.94%
 
1 Month
 
0.05%
 
3 Months
 
88.22%
 
1 Year
 
334.24%
 
5 Years
 
-54.50%
 

SYRE Analyst Ratings

  • Sell
  • Under
  • Hold
  • Over
  • Buy
Number of Ratings 17
Full Ratings ➔

About spyre therapeutics inc - SYRE

Spyre Therapeutics, Inc. is a clinical-stage biotechnology company, which engages in the development of next-generation human enzyme therapeutics as disruptive solutions for rare and other high-burden diseases. Its product, Pegzilarginase, is in a Phase 3 pivotal trial for the treatment of Arginase 1 Deficiency. The company was founded by George Georgiou and David G. Lowe on December 16, 2013 and is headquartered in Waltham, MA.

SYRE At a Glance

Spyre Therapeutics, Inc.
Building 23
Waltham, Massachusetts 02453
Phone 1-617-651-5940 Revenue 0.00
Industry Pharmaceuticals: Major Net Income -126,541,000.00
Sector Health Technology Employees 102
Fiscal Year-end 12 / 2026
View SEC Filings

SYRE Valuation

P/E Current N/A
P/E Ratio (with extraordinary items) N/A
P/E Ratio (without extraordinary items) N/A
Price to Sales Ratio N/A
Price to Book Ratio 4.579
Price to Cash Flow Ratio N/A
Enterprise Value to EBITDA -6.822
Enterprise Value to Sales N/A
Total Debt to Enterprise Value N/A

SYRE Efficiency

Revenue/Employee N/A
Income Per Employee -1,240,598.039
Receivables Turnover N/A
Total Asset Turnover N/A

SYRE Liquidity

Current Ratio 13.253
Quick Ratio 13.253
Cash Ratio 12.891

SYRE Profitability

Gross Margin N/A
Operating Margin N/A
Pretax Margin N/A
Net Margin N/A
Return on Assets -18.256
Return on Equity -20.525
Return on Total Capital -17.692
Return on Invested Capital -20.525

SYRE Capital Structure

Total Debt to Total Equity N/A
Total Debt to Total Capital N/A
Total Debt to Total Assets N/A
Long-Term Debt to Equity N/A
Long-Term Debt to Total Capital N/A
  • Income Statement
  • Balance Sheet
  • Cash Flow Statement

Annual Financials for Spyre Therapeutics Inc - SYRE

Collapse All in section
All values USD millions. 2022 2023 2024 2025 5-year trend
Sales/Revenue
- - 2.33M 886.00K
-
Sales Growth
- -87.57% -61.96% -100.00%
Cost of Goods Sold (COGS) incl D&A
- - 1.96M 964.00K
-
COGS excluding D&A
- - - -
-
Depreciation & Amortization Expense
- - 1.96M 964.00K
-
Depreciation
- - 1.96M 964.00K
-
Amortization of Intangibles
- - - -
-
COGS Growth
- -1.85% -50.92% -100.00%
Gross Income
- - 365.00K (78.00K)
-
Gross Income Growth
- -97.82% -121.37% +100.00%
Gross Profit Margin
- - +15.67% -8.80%
-
2022 2023 2024 2025 5-year trend
SG&A Expense
85.15M 117.53M 208.57M 219.56M
Research & Development
58.58M 84.05M 162.79M 171.65M
Other SG&A
26.57M 33.49M 45.78M 47.91M
SGA Growth
+3.35% +38.04% +77.45% +5.27%
Other Operating Expense
- - - -
-
Unusual Expense
- - - 224.67M
-
EBIT after Unusual Expense
(84.78M) (342.28M) (208.57M) (219.56M)
Non Operating Income/Expense
830.00K 3.47M 599.00K 64.34M
Non-Operating Interest Income
837.00K 6.15M 21.31M 24.89M
Equity in Earnings of Affiliates
- - - -
-
Interest Expense
- - - -
-
Interest Expense Growth
- - - -
-
Gross Interest Expense
- - - -
-
Interest Capitalized
- - - -
-
Pretax Income
(83.95M) (338.82M) (207.97M) (155.22M)
Pretax Income Growth
-27.86% -303.59% +38.62% +25.36%
Pretax Margin
- - -3,604.59% -38,241.08%
-
Income Tax
(136.00K) (26.00K) 51.00K (15.00K)
Income Tax - Current - Domestic
- - - -
-
Income Tax - Current - Foreign
- - - -
-
Income Tax - Deferred - Domestic
- - - -
-
Income Tax - Deferred - Foreign
- - - -
-
Income Tax Credits
- - - -
-
Equity in Earnings of Affiliates
- - - -
-
Other After Tax Income (Expense)
- 243.91M 58.46M 28.66M
Consolidated Net Income
(83.81M) (94.88M) (149.56M) (126.54M)
Minority Interest Expense
- - - -
-
Net Income
(83.81M) (94.88M) (149.56M) (126.54M)
Net Income Growth
-27.38% -13.21% -57.62% +15.39%
Net Margin Growth
- - -3,598.75% -10,709.14%
-
Extraordinaries & Discontinued Operations
- - - -
-
Discontinued Operations
- - - -
-
Net Income After Extraordinaries
(83.81M) (94.88M) (149.56M) (126.54M)
Preferred Dividends
- - - -
-
Net Income Available to Common
(83.81M) (94.88M) (149.56M) (126.54M)
EPS (Basic)
-24.8618 -13.757 -3.1801 -1.9755
EPS (Basic) Growth
+0.64% +44.67% +76.88% +37.88%
Basic Shares Outstanding
3.37M 6.90M 47.03M 64.06M
EPS (Diluted)
-24.8618 -13.757 -3.1801 -1.9755
EPS (Diluted) Growth
+0.64% +44.67% +76.88% +37.88%
Diluted Shares Outstanding
3.37M 6.90M 47.03M 64.06M
EBITDA
(82.82M) (116.65M) (208.57M) (219.56M)
EBITDA Growth
-30.12% -40.85% -78.80% -5.27%
EBITDA Margin
- - -3,555.90% -13,165.69%
-

Snapshot

Average Recommendation BUY Average Target Price 95.20
Number of Ratings 17 Current Quarters Estimate -0.732
FY Report Date 06 / 2026 Current Year's Estimate -2.933
Last Quarter’s Earnings -0.74 Median PE on CY Estimate N/A
Year Ago Earnings -1.98 Next Fiscal Year Estimate -3.186
Median PE on Next FY Estimate N/A

Earnings Per Share

This Quarter Next Quarter This Fiscal Next Fiscal
# of Estimates 15 15 15 15
Mean Estimate -0.73 -0.71 -2.93 -3.19
High Estimates -0.49 -0.51 -2.29 -1.61
Low Estimate -0.90 -0.95 -3.78 -4.63
Coefficient of Variance -17.30 -18.56 -13.70 -24.20

Analysts Recommendations

Current 1 Month Ago 3 Months Ago
BUY 16 16 14
OVERWEIGHT 1 1 1
HOLD 0 0 0
UNDERWEIGHT 0 0 0
SELL 0 0 0
MEAN Buy Buy Buy

Spyre Therapeutics Inc in the News