septerna inc - SEPN

SEPN

Close Chg Chg %
24.37 0.81 3.32%

Closed Market

25.18

+0.81 (3.32%)

Volume: 288.09K

Last Updated:

Apr 2, 2026, 4:00 PM EDT

Company Overview: septerna inc - SEPN

SEPN Key Data

Open

$23.90

Day Range

23.90 - 25.29

52 Week Range

4.66 - 32.63

Market Cap

$1.13B

Shares Outstanding

44.91M

Public Float

27.01M

Beta

3.50

Rev. Per Employee

N/A

P/E Ratio

N/A

EPS

-$1.11

Yield

0.00%

Dividend

N/A

EX-DIVIDEND DATE

SHORT INTEREST

N/A

AVERAGE VOLUME

277.59K

 

SEPN Performance

1 Week
 
5.49%
 
1 Month
 
-12.51%
 
3 Months
 
-10.01%
 
1 Year
 
359.49%
 
5 Years
 
N/A
 

SEPN Analyst Ratings

  • Sell
  • Under
  • Hold
  • Over
  • Buy
Number of Ratings 8
Full Ratings ➔

About septerna inc - SEPN

Septerna, Inc. is a clinical-stage biotechnology company, which engages in pioneering a new era of G protein-coupled receptor oral small molecule drug discovery powered by proprietary Native Complex PlatformTM. Its pipeline of product candidates focused initially on treating patients in three therapeutic areas: endocrinology, immunology and inflammation, and metabolic diseases. The company was founded by Robert Joseph Lefkowitz, Arthur Christopoulos, Patrick Sexton, and Jeffrey T. Finer in December 2019 and is headquartered in South San Francisco, CA.

SEPN At a Glance

Septerna, Inc.
250 East Grand Avenue
South San Francisco, California 94080
Phone 1-650-338-3533 Revenue 45.95M
Industry Biotechnology Net Income -48,879,000.00
Sector Health Technology 2025 Sales Growth 4,174.512%
Fiscal Year-end 12 / 2026 Employees 130
View SEC Filings

SEPN Valuation

P/E Current N/A
P/E Ratio (with extraordinary items) N/A
P/E Ratio (without extraordinary items) N/A
Price to Sales Ratio 26.853
Price to Book Ratio 3.271
Price to Cash Flow Ratio 11.20
Enterprise Value to EBITDA -10.941
Enterprise Value to Sales 18.856
Total Debt to Enterprise Value 0.027

SEPN Efficiency

Revenue/Employee 353,469.231
Income Per Employee -375,992.308
Receivables Turnover 3.344
Total Asset Turnover 0.087

SEPN Liquidity

Current Ratio 4.727
Quick Ratio 4.727
Cash Ratio 4.499

SEPN Profitability

Gross Margin 96.509
Operating Margin -175.833
Pretax Margin -106.346
Net Margin -106.372
Return on Assets -9.235
Return on Equity -12.19
Return on Total Capital -12.052
Return on Invested Capital -11.542

SEPN Capital Structure

Total Debt to Total Equity 6.186
Total Debt to Total Capital 5.825
Total Debt to Total Assets 3.925
Long-Term Debt to Equity 5.607
Long-Term Debt to Total Capital 5.28
  • Income Statement
  • Balance Sheet
  • Cash Flow Statement

Annual Financials for Septerna Inc - SEPN

Collapse All in section
All values USD millions. 2022 2023 2024 2025 5-year trend
Sales/Revenue
- 151.00K 1.07M 45.95M
Sales Growth
- - +611.92% +4,174.51%
-
Cost of Goods Sold (COGS) incl D&A
577.00K 848.00K 1.40M 1.60M
COGS excluding D&A
- - - -
-
Depreciation & Amortization Expense
577.00K 848.00K 1.40M 1.60M
Depreciation
- - 1.40M 1.60M
-
Amortization of Intangibles
- - - -
-
COGS Growth
- +46.97% +65.21% +14.49%
Gross Income
(577.00K) (697.00K) (326.00K) 44.35M
Gross Income Growth
- -20.80% +53.23% +13,703.37%
Gross Profit Margin
- -461.59% -30.33% +96.51%
2022 2023 2024 2025 5-year trend
SG&A Expense
27.39M 44.85M 80.50M 125.14M
Research & Development
22.04M 35.98M 65.34M 97.58M
Other SG&A
5.35M 8.87M 15.16M 27.56M
SGA Growth
- +63.76% +79.47% +55.46%
Other Operating Expense
- - - -
-
Unusual Expense
- - - -
-
EBIT after Unusual Expense
(27.97M) (45.55M) (80.82M) (80.80M)
Non Operating Income/Expense
291.00K 50.42M 8.53M 31.93M
Non-Operating Interest Income
291.00K 2.79M 8.62M 19.53M
Equity in Earnings of Affiliates
- - - -
-
Interest Expense
- - - -
-
Interest Expense Growth
- - - -
-
Gross Interest Expense
- - - -
-
Interest Capitalized
- - - -
-
Pretax Income
(27.68M) 4.87M (72.30M) (48.87M)
Pretax Income Growth
- +117.60% -1,584.21% +32.41%
Pretax Margin
- +3,225.83% -6,725.21% -106.35%
Income Tax
- 691.00K (498.00K) 12.00K
Income Tax - Current - Domestic
- 200.00K (7.00K) 12.00K
Income Tax - Current - Foreign
- - - -
-
Income Tax - Deferred - Domestic
- - 491.00K (491.00K)
-
Income Tax - Deferred - Foreign
- - - -
-
Income Tax Credits
- - - -
-
Equity in Earnings of Affiliates
- - - -
-
Other After Tax Income (Expense)
- - - (3.61M)
-
Consolidated Net Income
(27.68M) 567.00K (71.80M) (48.88M)
Minority Interest Expense
- - - -
-
Net Income
(27.68M) 567.00K (71.80M) (48.88M)
Net Income Growth
- +102.05% -12,762.79% +31.92%
Net Margin Growth
- +375.50% -6,678.88% -106.37%
Extraordinaries & Discontinued Operations
- - - -
-
Discontinued Operations
- - - -
-
Net Income After Extraordinaries
(27.68M) 567.00K (71.80M) (48.88M)
Preferred Dividends
- - - -
-
Net Income Available to Common
(27.68M) 567.00K (71.80M) (48.88M)
EPS (Basic)
-0.6589 0.0135 -1.6162 -1.1044
EPS (Basic) Growth
- +102.05% -12,071.85% +31.67%
Basic Shares Outstanding
42.00M 42.00M 44.42M 44.26M
EPS (Diluted)
-0.6589 0.0135 -1.6162 -1.1044
EPS (Diluted) Growth
- +102.05% -12,071.85% +31.67%
Diluted Shares Outstanding
42.00M 42.00M 44.42M 44.26M
EBITDA
(27.39M) (44.70M) (79.42M) (79.19M)
EBITDA Growth
- -63.21% -77.67% +0.29%
EBITDA Margin
- -29,603.97% -7,388.09% -172.34%

Snapshot

Average Recommendation BUY Average Target Price 45.50
Number of Ratings 8 Current Quarters Estimate -0.318
FY Report Date 06 / 2026 Current Year's Estimate -1.576
Last Quarter’s Earnings -0.324 Median PE on CY Estimate N/A
Year Ago Earnings -1.10 Next Fiscal Year Estimate -2.299
Median PE on Next FY Estimate N/A

Earnings Per Share

This Quarter Next Quarter This Fiscal Next Fiscal
# of Estimates 8 8 8 8
Mean Estimate -0.32 -0.34 -1.58 -2.30
High Estimates -0.07 0.46 -0.40 -1.20
Low Estimate -0.69 -0.75 -2.77 -3.51
Coefficient of Variance -66.20 -113.82 -49.25 -32.46

Analysts Recommendations

Current 1 Month Ago 3 Months Ago
BUY 8 8 8
OVERWEIGHT 0 0 0
HOLD 0 0 0
UNDERWEIGHT 0 0 0
SELL 0 0 0
MEAN Buy Buy Buy

Insider Actions for Septerna Inc - SEPN

Date Name Shares Transaction Value
Apr 7, 2025 Jeffrey T. Finer CEO and President; Director 821,907 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 Non-derivative transaction at $2.76 per share 2,268,463.32
Apr 7, 2025 Jeffrey T. Finer CEO and President; Director 826,907 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 Non-derivative transaction at $2.76 per share 2,282,263.32
Apr 7, 2025 Jeffrey T. Finer CEO and President; Director 402,212 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 0.00
Apr 7, 2025 Jeffrey T. Finer CEO and President; Director 397,212 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 0.00

Septerna Inc in the News