karyopharm therapeutics inc - KPTI

KPTI

Close Chg Chg %
5.82 0.07 1.20%

Closed Market

5.89

+0.07 (1.20%)

Volume: 185.42K

Last Updated:

Apr 2, 2026, 4:00 PM EDT

Company Overview: karyopharm therapeutics inc - KPTI

KPTI Key Data

Open

$5.61

Day Range

5.50 - 6.10

52 Week Range

3.51 - 10.99

Market Cap

$108.05M

Shares Outstanding

18.34M

Public Float

16.99M

Beta

0.40

Rev. Per Employee

N/A

P/E Ratio

N/A

EPS

-$16.62

Yield

0.00%

Dividend

N/A

EX-DIVIDEND DATE

SHORT INTEREST

N/A

AVERAGE VOLUME

1.67M

 

KPTI Performance

1 Week
 
7.48%
 
1 Month
 
-32.84%
 
3 Months
 
-18.08%
 
1 Year
 
52.59%
 
5 Years
 
-96.38%
 

KPTI Analyst Ratings

  • Sell
  • Under
  • Hold
  • Over
  • Buy
Number of Ratings 8
Full Ratings ➔

About karyopharm therapeutics inc - KPTI

Karyopharm Therapeutics, Inc. is a commercial-stage pharmaceutical company, which engages in the discovery, development, and commercialization of drugs directed against nuclear export for the treatment of cancer and other diseases. The company was founded by Joseph Araujo, Ronald A. DePinho, Pamela A, Silver, Giulio Draetta, Michael G. Kauffman, and Sharon Shacham on December 22, 2008, and is headquartered in Newton, MA.

KPTI At a Glance

Karyopharm Therapeutics, Inc.
85 Wells Avenue
Newton, Massachusetts 02459-3298
Phone 1-617-658-0600 Revenue 146.07M
Industry Pharmaceuticals: Major Net Income -196,039,000.00
Sector Health Technology 2025 Sales Growth 0.571%
Fiscal Year-end 12 / 2026 Employees 228
View SEC Filings

KPTI Valuation

P/E Current N/A
P/E Ratio (with extraordinary items) N/A
P/E Ratio (without extraordinary items) N/A
Price to Sales Ratio 0.551
Price to Book Ratio N/A
Price to Cash Flow Ratio N/A
Enterprise Value to EBITDA -2.769
Enterprise Value to Sales 1.714
Total Debt to Enterprise Value 0.933

KPTI Efficiency

Revenue/Employee 640,644.737
Income Per Employee -859,820.175
Receivables Turnover 5.58
Total Asset Turnover 1.036

KPTI Liquidity

Current Ratio 1.12
Quick Ratio 1.077
Cash Ratio 0.692

KPTI Profitability

Gross Margin 95.725
Operating Margin -62.10
Pretax Margin -134.182
Net Margin -134.212
Return on Assets -139.097
Return on Equity N/A
Return on Total Capital 330.483
Return on Invested Capital N/A

KPTI Capital Structure

Total Debt to Total Equity N/A
Total Debt to Total Capital -393.815
Total Debt to Total Assets 198.891
Long-Term Debt to Equity N/A
Long-Term Debt to Total Capital -356.763
  • Income Statement
  • Balance Sheet
  • Cash Flow Statement

Annual Financials for Karyopharm Therapeutics Inc - KPTI

Collapse All in section
All values USD millions. 2022 2023 2024 2025 5-year trend
Sales/Revenue
157.07M 146.03M 145.24M 146.07M
Sales Growth
-25.14% -7.03% -0.55% +0.57%
Cost of Goods Sold (COGS) incl D&A
5.83M 5.47M 6.35M 6.25M
COGS excluding D&A
- - - -
-
Depreciation & Amortization Expense
621.00K 530.00K 340.00K 296.00K
Depreciation
621.00K 530.00K 340.00K 296.00K
Amortization of Intangibles
- - - -
-
COGS Growth
+39.20% -6.21% +15.99% -1.61%
Gross Income
151.24M 140.56M 138.89M 139.82M
Gross Income Growth
-26.45% -7.06% -1.19% +0.67%
Gross Profit Margin
+96.29% +96.25% +95.63% +95.72%
2022 2023 2024 2025 5-year trend
SG&A Expense
293.44M 270.10M 258.33M 230.53M
Research & Development
148.04M 138.22M 142.89M 125.32M
Other SG&A
145.40M 131.88M 115.44M 105.21M
SGA Growth
-1.05% -7.95% -4.36% -10.76%
Other Operating Expense
- - - -
-
Unusual Expense
- (280.00K) (44.70M) 62.37M
EBIT after Unusual Expense
(141.92M) (129.54M) (74.74M) (153.07M)
Non Operating Income/Expense
2.00M 10.59M 35.80M 2.92M
Non-Operating Interest Income
2.36M 10.94M 7.40M 2.77M
Equity in Earnings of Affiliates
- - - -
-
Interest Expense
25.00M 23.82M 37.42M 45.85M
Interest Expense Growth
-4.03% -4.69% +57.08% +22.52%
Gross Interest Expense
25.00M 23.82M 37.42M 45.85M
Interest Capitalized
- - - -
-
Pretax Income
(164.92M) (142.78M) (76.36M) (196.00M)
Pretax Income Growth
-33.19% +13.43% +46.51% -156.66%
Pretax Margin
-105.00% -97.77% -52.58% -134.18%
Income Tax
369.00K 323.00K 57.00K 43.00K
Income Tax - Current - Domestic
- - - -
-
Income Tax - Current - Foreign
- - - -
-
Income Tax - Deferred - Domestic
- - - -
-
Income Tax - Deferred - Foreign
- - - -
-
Income Tax Credits
- - - -
-
Equity in Earnings of Affiliates
- - - -
-
Other After Tax Income (Expense)
- - - -
-
Consolidated Net Income
(165.29M) (143.10M) (76.42M) (196.04M)
Minority Interest Expense
- - - -
-
Net Income
(165.29M) (143.10M) (76.42M) (196.04M)
Net Income Growth
-33.20% +13.43% +46.60% -156.52%
Net Margin Growth
-105.23% -97.99% -52.62% -134.21%
Extraordinaries & Discontinued Operations
- - - -
-
Discontinued Operations
- - - -
-
Net Income After Extraordinaries
(165.29M) (143.10M) (76.42M) (196.04M)
Preferred Dividends
- - - -
-
Net Income Available to Common
(165.29M) (143.10M) (76.42M) (196.04M)
EPS (Basic)
-30.2838 -18.7925 -9.4067 -17.9277
EPS (Basic) Growth
-22.38% +37.95% +49.94% -90.58%
Basic Shares Outstanding
5.46M 7.61M 8.12M 10.94M
EPS (Diluted)
-30.2838 -18.7925 -9.4067 -17.9277
EPS (Diluted) Growth
-22.38% +37.95% +49.94% -90.58%
Diluted Shares Outstanding
5.46M 7.61M 8.12M 10.94M
EBITDA
(141.58M) (129.01M) (119.10M) (90.41M)
EBITDA Growth
-57.09% +8.88% +7.68% +24.09%
EBITDA Margin
-90.14% -88.34% -82.01% -61.90%

Snapshot

Average Recommendation BUY Average Target Price 13.857
Number of Ratings 8 Current Quarters Estimate -1.183
FY Report Date 06 / 2026 Current Year's Estimate -4.451
Last Quarter’s Earnings -1.51 Median PE on CY Estimate N/A
Year Ago Earnings -17.93 Next Fiscal Year Estimate -3.20
Median PE on Next FY Estimate N/A

Earnings Per Share

This Quarter Next Quarter This Fiscal Next Fiscal
# of Estimates 7 7 7 6
Mean Estimate -1.18 -1.00 -4.45 -3.20
High Estimates -0.47 -0.71 -3.17 -1.24
Low Estimate -1.88 -1.52 -6.22 -6.32
Coefficient of Variance -41.71 -28.22 -24.24 -56.64

Analysts Recommendations

Current 1 Month Ago 3 Months Ago
BUY 6 6 4
OVERWEIGHT 1 1 1
HOLD 1 1 1
UNDERWEIGHT 0 0 0
SELL 0 0 0
MEAN Buy Buy Overweight

Insider Actions for Karyopharm Therapeutics Inc - KPTI

Date Name Shares Transaction Value
Feb 20, 2026 Stuart Poulton EVP, Chief Development Officer 99,429 Open market or private sale of non-derivative or derivative security Non-derivative transaction at $8.63 per share 858,072.27
Jan 23, 2026 Kristin Abate Chief Accounting Officer 22,580 Open market or private sale of non-derivative or derivative security Non-derivative transaction at $5.96 per share 134,576.80
Apr 8, 2025 Richard A. Paulson President and CEO; Director 82,739 Open market or private sale of non-derivative or derivative security Non-derivative transaction at $3.74 per share 309,443.86

Karyopharm Therapeutics Inc in the News