denali therapeutics inc - DNLI

DNLI

Close Chg Chg %
19.30 -0.66 -3.42%

Closed Market

18.64

-0.66 (3.42%)

Volume: 3.56M

Last Updated:

May 22, 2026, 4:00 PM EDT

Company Overview: denali therapeutics inc - DNLI

DNLI Key Data

Open

$18.52

Day Range

18.18 - 19.06

52 Week Range

12.58 - 23.77

Market Cap

$3.06B

Shares Outstanding

158.71M

Public Float

141.60M

Beta

0.99

Rev. Per Employee

N/A

P/E Ratio

N/A

EPS

-$2.88

Yield

0.00%

Dividend

N/A

EX-DIVIDEND DATE

SHORT INTEREST

N/A

AVERAGE VOLUME

1.88M

 

DNLI Performance

1 Week
 
0.11%
 
1 Month
 
-6.19%
 
3 Months
 
-11.99%
 
1 Year
 
38.90%
 
5 Years
 
-68.35%
 

DNLI Analyst Ratings

  • Sell
  • Under
  • Hold
  • Over
  • Buy
Number of Ratings 19
Full Ratings ➔

About denali therapeutics inc - DNLI

Denali Therapeutics, Inc. is a biopharmaceutical company, which engages in the development and commercialization of a portfolio of product candidates for neurodegenerative diseases. Its product pipeline includes LRRK2, RIPK1, TREM2, and Tau. The company was founded by Ryan J. Watts, Marc Tessier-Lavigne, and Alexander Schuth on October 14, 2013 and is headquartered in San Francisco, CA.

DNLI At a Glance

Denali Therapeutics, Inc.
161 Oyster Point Boulevard
San Francisco, California 94080
Phone 1-650-866-8547 Revenue 0.00
Industry Biotechnology Net Income -512,540,000.00
Sector Health Technology Employees 503
Fiscal Year-end 12 / 2026
View SEC Filings

DNLI Valuation

P/E Current N/A
P/E Ratio (with extraordinary items) N/A
P/E Ratio (without extraordinary items) N/A
Price to Sales Ratio N/A
Price to Book Ratio 2.544
Price to Cash Flow Ratio N/A
Enterprise Value to EBITDA -3.746
Enterprise Value to Sales N/A
Total Debt to Enterprise Value 0.021

DNLI Efficiency

Revenue/Employee N/A
Income Per Employee -1,018,966.203
Receivables Turnover N/A
Total Asset Turnover N/A

DNLI Liquidity

Current Ratio 9.158
Quick Ratio 9.158
Cash Ratio 8.824

DNLI Profitability

Gross Margin N/A
Operating Margin N/A
Pretax Margin N/A
Net Margin N/A
Return on Assets -40.693
Return on Equity -45.692
Return on Total Capital -48.534
Return on Invested Capital -44.214

DNLI Capital Structure

Total Debt to Total Equity 4.171
Total Debt to Total Capital 4.004
Total Debt to Total Assets 3.694
Long-Term Debt to Equity 3.23
Long-Term Debt to Total Capital 3.10
  • Income Statement
  • Balance Sheet
  • Cash Flow Statement

Annual Financials for Denali Therapeutics Inc - DNLI

Collapse All in section
All values USD millions. 2022 2023 2024 2025 5-year trend
Sales/Revenue
- - 108.46M 330.53M
-
Sales Growth
- +122.90% +204.74% -100.00%
Cost of Goods Sold (COGS) incl D&A
7.03M 16.73M 7.79M 14.81M
COGS excluding D&A
- - - -
-
Depreciation & Amortization Expense
7.03M 16.73M 7.79M 14.81M
Depreciation
7.03M 16.73M 7.79M 14.81M
Amortization of Intangibles
- - - -
-
COGS Growth
+25.37% +137.86% -53.40% +90.02%
Gross Income
101.43M 313.81M (7.79M) (14.81M)
Gross Income Growth
+135.60% +209.38% -102.48% -90.02%
Gross Profit Margin
- - +93.52% +94.94%
-
2022 2023 2024 2025 5-year trend
SG&A Expense
442.18M 510.50M 494.08M 540.53M
Research & Development
358.73M 423.88M 396.44M 418.78M
Other SG&A
83.44M 86.63M 97.64M 121.75M
SGA Growth
+30.51% +15.45% -3.22% +9.40%
Other Operating Expense
- - - -
-
Unusual Expense
- - - -
-
EBIT after Unusual Expense
(340.74M) (196.70M) (501.88M) (555.34M)
Non Operating Income/Expense
14.77M 51.51M 79.17M 42.90M
Non-Operating Interest Income
14.77M 51.51M 64.64M 42.90M
Equity in Earnings of Affiliates
- - - -
-
Interest Expense
- - - -
-
Interest Expense Growth
- - - -
-
Gross Interest Expense
- - - -
-
Interest Capitalized
- - - -
-
Pretax Income
(325.97M) (145.19M) (422.70M) (512.44M)
Pretax Income Growth
-11.96% +55.46% -191.13% -21.23%
Pretax Margin
- - -300.54% -43.93%
-
Income Tax
21.00K 30.00K 68.00K 102.00K
Income Tax - Current - Domestic
- - - 7.00K
-
Income Tax - Current - Foreign
14.00K 30.00K 68.00K 102.00K
Income Tax - Deferred - Domestic
- - - -
-
Income Tax - Deferred - Foreign
- - - -
-
Income Tax Credits
- - - -
-
Equity in Earnings of Affiliates
- - - -
-
Other After Tax Income (Expense)
- - - -
-
Consolidated Net Income
(325.99M) (145.22M) (422.77M) (512.54M)
Minority Interest Expense
- - - -
-
Net Income
(325.99M) (145.22M) (422.77M) (512.54M)
Net Income Growth
-12.19% +55.45% -191.12% -21.23%
Net Margin Growth
- - -300.56% -43.94%
-
Extraordinaries & Discontinued Operations
- - - -
-
Discontinued Operations
- - - -
-
Net Income After Extraordinaries
(325.99M) (145.22M) (422.77M) (512.54M)
Preferred Dividends
- - - -
-
Net Income Available to Common
(325.99M) (145.22M) (422.77M) (512.54M)
EPS (Basic)
-2.5969 -1.0572 -2.5705 -2.9687
EPS (Basic) Growth
-8.61% +59.29% -143.14% -15.49%
Basic Shares Outstanding
125.53M 137.37M 164.47M 172.65M
EPS (Diluted)
-2.5969 -1.0572 -2.5705 -2.9687
EPS (Diluted) Growth
-8.61% +59.29% -143.14% -15.49%
Diluted Shares Outstanding
125.53M 137.37M 164.47M 172.65M
EBITDA
(333.71M) (179.97M) (494.08M) (540.53M)
EBITDA Growth
-15.02% +46.07% -174.53% -9.40%
EBITDA Margin
- - -307.67% -54.45%
-

Snapshot

Average Recommendation BUY Average Target Price 34.667
Number of Ratings 19 Current Quarters Estimate -0.592
FY Report Date 06 / 2026 Current Year's Estimate -2.462
Last Quarter’s Earnings -0.69 Median PE on CY Estimate N/A
Year Ago Earnings -2.97 Next Fiscal Year Estimate -2.429
Median PE on Next FY Estimate N/A

Earnings Per Share

This Quarter Next Quarter This Fiscal Next Fiscal
# of Estimates 17 19 19 19
Mean Estimate -0.59 -0.59 -2.46 -2.43
High Estimates 0.34 0.19 -1.70 -1.56
Low Estimate -0.89 -0.90 -3.11 -2.89
Coefficient of Variance -59.60 -50.87 -18.91 -14.97

Analysts Recommendations

Current 1 Month Ago 3 Months Ago
BUY 17 17 16
OVERWEIGHT 1 1 1
HOLD 1 1 1
UNDERWEIGHT 0 0 0
SELL 0 0 0
MEAN Buy Buy Buy

Denali Therapeutics Inc in the News