Why Seres Therapeutics Inc. Is Being Obliterated Today

By Brian FeroldiMarketsFool.com

Image source: Getty Images.

What: Shares of Seres Therapeutics(NASDAQ: MCRB), a clinical-stage biotech focused on developingmicrobiome technology,are collapsing today, down more than 71% as of noon EDT, on huge volume in response to the news that an important clinical study didn't go according to plan.

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So what: Seres Therapeutics released interim results from its ECOSPOR study today, which was testing its lead product candidate, SER-109, as a potential treatment for the bacterium Clostridium difficile, or C. diff.

The 89-patient, placebo-controlled phase 2 study was attempting to show that usingSER-109 could reduce the relative risk of C. diff infection (CDI) recurrence. Unfortunately, the company's interim data that were collected at week eight of the study showed SER-109 has failed to meet its primary objective.

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Specifically, CDI recurrence was observed in 44% of patients who used SER-109, compared to 53% of patients who used a placebo. Even though the result for Seres' product was slightly better, it was not high enough to be statistically significant.

Seres Therapeutics' CEO, Roger Pomerantz, offered up this commentary on the disappointing study results:

Now what: SER-109 was the company's most advanced product candidate, so it's no surprise to see Seres shares getting wiped out today.

If you're looking for a silver lining here, the study hinted that SER-190 may still hold promise as a treatment for older adults. Specially, subjects who were older than 65 and used SER-190 experienced CDI recurrence in only 45% of cases, which compared favorably to the 80% recurrence observed in the placebo group. Still, that number was from a much smaller patient population, so it's possible that the result occurred purely by chance. In addition, SER-190 performed far worse with the younger patient population: SER-190 was associated with CDI recurrence in 43% of subjects under age 65, versus only 27% in the placebo group.

Seres Therapeutics' stock has put investors on a rough ride since first hitting the public markets in June 2015. Even prior to today's collapse, shares trailed the poorly performing biotech index ingeneral, as measured by theSPDR S&P Biotech ETF (NYSEMKT: XBI).

MCRB data by YCharts.

With huge questions in the air regarding this company's future, it's hard to find a reason to be bullish on the company's shares. Even though shares are much cheaper today than they were yesterday, I'd advise risk-loving investors to look elsewhere for more promising opportunities.

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Brian Feroldi has no position in any stocks mentioned.Like this article? Follow him onTwitter where he goes by the handle@Longtermmindsetor connect with him on LinkedIn to see more articles like this.

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