Why Clearside Biomedical, Inc. Stock Gained 66.1% March

What happened

Clearside Biomedical, Inc. Stock (NASDAQ: CLSD) stock rose 66.1% in March, according to data provided by S&P Global Market Intelligence.

The company published an update on March 5 reporting promising phase 3 trial results for its drug CLS-TA as a uveitis-related macular edema treatment. Clearside Biomedical is a small-cap company with a valuation of roughly $300 million that had heavy short interest prior to the announcement, so the favorable news regarding the efficacy of CLS-TA sent shares soaring and prompted additional momentum as short-sellers moved to cover their positions.

So what

In one trial, 46.9% of patients who received CLS-TA saw dramatic improvements on vision-test performance. These test subjects were able to identify at least 15 additional letters on the standardized vision exam, while only 15.6% of patients in the placebo group saw the same improvement. Testing also showed little in the way of negative side effects for the drug. Approximately 11.5% of study participants reported increased intraocular pressure, but this side effect was not considered to present significant risk. The encouraging trial data suggests that Clearside Biomedical's CLS-TA drug could be poised for approval as an uveitis-related macular edema treatment.

Now what

The company will release more in depth results from its recent CLS-TA trials at an upcoming medical conference. On the heels of the promising macular-edema treatment trial results, attention turns to whether the FDA will approve the marketing of CLS-TA and for what purposes. Clearside expects that it will submit a new drug application for CLS-TA to the regulatory agency in the fourth quarter of 2018, and it's also testing the drug as a treatment for macular edema associated with retinal occlusion and plans to report preliminary results from these trials in the same time window.

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Keith Noonan has no position in any of the stocks mentioned. The Motley Fool has no position in any of the stocks mentioned. The Motley Fool has a disclosure policy.