U.S. trade officials will press China to allow greater market access for American goods and services during meetings this week in Chicago.
A Chinese trade delegation arrives Tuesday. Talks run through Thursday.
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It's the first time that the annual meeting of the U.S.-China Joint Commission on Commerce and Trade will be held in Chicago.
Participants will try to make progress on an investment treaty that the two countries have been negotiating.
U.S. Trade Representative Michael Froman says key topics include protection of intellectual property and trade secrets as well as ensuring there's a level playing field for U.S. companies in China.
American companies say a treaty would help make operating conditions in China's state-dominated economy clearer and more predictable.
Trade between the two countries totaled $617 billion last year.