Stocks that moved substantially or traded heavily Tuesday on the New York Stock Exchange and the Nasdaq Stock Market:
Novartis AG, up $3.43 to $93.47
The drug developer presented positive data for a potential heart-failure drug and will ask for approval by the end of the year.
Las Vegas Sands Corp., down $3.41 to $63.10
The casino operator and its gambling company peers experienced a decline in revenue from the gambling hub Macau during August.
Cloud Peak Energy Inc., down $1.27 to $14.44
The coal company lowered its coal shipment and adjusted earnings guidance for 2014, citing rail issues and weather impacts.
Crown Holdings Inc., up $1.85 to $50.12
The packaging products company is buying the Mexican can packaging business of brewer Heineken for just under $1.23 billion.
Exelixis Inc., down $2.29 to $1.85
The biotechnology company said its potential treatment for prostate cancer failed to meet a key goal in a late-stage study.
Conns Inc., down $13.83 to $31
The consumer goods retailer reported second-quarter profit below Wall Street expectations and cut its full-year profit guidance.
Norwegian Cruise Line Holdings Ltd., up $3.68 to $36.99
The cruise line will buy Prestige Cruises International for about $3 billion and expects to close the deal in the fourth quarter.
Acadia Pharmaceuticals Inc., up $2.63 to $26.61
The biotechnology company received a special FDA designation for its potential Parkinson's disease psychosis treatment, Nuplazid.