The latest on developments in financial markets (All times local):
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Big drops in several health care companies are taking stock indexes lower in early trading on Wall Street.
Drugmaker Eli Lilly plunged 14 percent early Wednesday after it said a potential treatment for Alzheimer's disease failed in a clinical trial.
Other health care stocks also fell. Biogen slumped 6 percent.
Agricultural equipment maker Deere & Co. soared 8 percent after reporting strong results for its latest quarter.
The Dow Jones industrial average slipped 4 points, less than 0.1 percent, to 19,019. The Standard & Poor's 500 index fell 5 points, or 0.5 percent, to 2,197. The Nasdaq composite declined 29 points, or 0.5 percent, to 5,357.
U.S. markets will be closed Thursday for Thanksgiving.