Here's Why Sage Therapeutics' Stock Is Falling Today

By George

What: Shares of Sage Therapeutics fell by more than 20% in early morning trading Wednesday on heavy volume. The catalyst behind this downward move was a 28-page report issued by Kerrisdale Capital stating that the company's lead experimental product candidateSAGE-547 -- indicated for super-refractory status epilepticus (SRSE) -- is either likely to fail its ongoing late-stage trial, or turn out to be a commercial failure due to the presence of similar drugs on the market like benzodiazepines, anti-epileptics, and anesthetics that arealready used to treat SRSE.

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Image source: Creative Commons via Gerry Shaw.

The firm also believes, according to the report, that Sage is overestimating the size of the drug's target market by perhaps a factor of 6, implying that SAGE-547 would, at best, be a minor drug from a revenue standpoint, if approved.

SRSE is a rare, yet deadly, condition characterized by persistent seizures that fail to respond to standard forms of therapies.

So what:Kerrisdale Capital thinks Sage's shares could drop by as much as 70% from current levels, given that the company's remaining clinical assets are mostly in the early stages of development. In short, Kerrisdale Capital is essentially valuing Sage at a little over its last stated cash position of around $186 million.

Now what: Sage is expected to release top-line results fromSAGE-547's late-stage trial in the second half of 2016, which will be the moment of truth for the biotech. While I don't have a crystal ball to predict the outcome of this particular clinical trial, the fact of the matter is that Sage's stock could very well crash if its lead product candidatemisses the mark later this year. Unfortunately, that's a common theme among clinical-stage biotechs in general, and a big reason why I generally avoid these types of ultra-risky stocks.

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George Budwell has no position in any stocks mentioned. The Motley Fool has no position in any of the stocks mentioned. Try any of our Foolish newsletter services free for 30 days. We Fools may not all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors. The Motley Fool has a disclosure policy.

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