The museum, which is now the Kennth C. Griffin Museum of Science and Industry, announced the change after hedge-fund titan Griffin donated $125 million, the largest gift in the institution's history.
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"Seriously? Why do all these ego-maniacal billionaires have to slap their name on everything?" Twitter user Sarah Laird wrote on Thursday.
Griffin has a net worth of $12.5 billion, according to Forbes.
Here are some other reactions to the name change from social media users.
Not everyone had a negative outlook, however.