As of 5 p.m. Eastern time, 209 flights had been canceled for this evening and an additional 91 were delayed, according to Flight Aware.
Pictures taken at Minneapolis−Saint Paul airport on Friday show a snowy tarmac with crews assisting in removing the snow.
The weather system is expected to last all weekend and drop up to 14 inches of snow in some parts of the Upper Peninsula of Michigan.
Winter weather alerts have been issued by the National Weather Service for parts of Nebraska, South Dakota, Iowa, Minnesota, Wisconsin and Michigan.
In addition to airport delays, snow and slush is being reported on many streets and highways in the metro area of Minneapolis and St. Paul.
The Minneapolis−Saint Paul airport asked travelers on Friday afternoon to check their flight status before heading to the airport.
Significantly higher snowfall rates are expected to the south of the Twin Cities, where some areas south of Minneapolis such as Faribault could see anywhere between 8-12 inches of snow.
The City of Minneapolis has also declared a snow emergency, which prevents drivers from parking on snow emergency routes, allowing plow trucks to clear roads.