Shire plc Shire Plc : Directorate Change

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Chief Financial Officer update

December 8, 2017 - Shire plc (LSE: SHP, NASDAQ: SHPG), the global

biotech leader in rare diseases, announced on August 21, 2017, that Jeff

Poulton, Chief Financial Officer, would leave Shire at the end of the

year. On November 20, 2017, Shire announced that Thomas Dittrich will

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join the company as Chief Financial Officer in early 2018.

Shire today announces that Jeff Poulton will leave on December 31, 2017,

and John Miller, Shire's Senior Vice President of Finance, will be

appointed Interim Chief Financial Officer with effect from January 1,

2018, until Mr. Dittrich commences his employment with Shire.

Mr. Miller joined Shire in 2004 and, in addition to his current role in

which he has served since March 2015, has served in a number of

positions including, in the past five years, as Vice President of

Finance, Neuroscience from June 2010 to March 2015.

For further information please contact:

Investor Relations

Ian Karp ikarp@shire.com +1 781 482 9018

Robert Coates rcoates@shire.com +44 203 549 0874

Media

Lisa Adler lisa.adler@shire.com +1 617 588 8607

Katie Joyce kjoyce@shire.com +1 781 482 2779

NOTES TO EDITORS

About Shire

Shire is the global leader in serving patients with rare diseases. We

strive to develop best-in-class therapies across a core of rare disease

areas including hematology, immunology, genetic diseases, neuroscience,

and internal medicine with growing therapeutic areas in ophthalmics and

oncology. Our diversified capabilities enable us to reach patients in

more than 100 countries who are struggling to live their lives to the

fullest.

We feel a strong sense of urgency to address unmet medical needs and

work tirelessly to improve people's lives with medicines that have a

meaningful impact on patients and all who support them on their journey.

www.shire.com

This announcement is distributed by Nasdaq Corporate Solutions on behalf

of Nasdaq Corporate Solutions clients.

The issuer of this announcement warrants that they are solely

responsible for the content, accuracy and originality of the information

contained therein.

Source: Shire plc via Globenewswire

(END) Dow Jones Newswires

December 08, 2017 11:15 ET (16:15 GMT)