Here's Why CRISPR Therapeutics Has Lost One-Third of Its Value Since September

MarketsMotley Fool

What happened

Shares of CRISPR Therapeutics (NASDAQ: CRSP) fell 21.7% last month and 33.3% in the last six weeks, according to data provided by S&P Global Market Intelligence. The stock market's most valuable CRISPR stock by market cap has been falling back to earth in recent months after briefly eclipsing a $3 billion valuation earlier this summer.

Continue Reading Below

In addition to investors slowly readjusting the biopharma's market cap over time, CRISPR Therapeutics stock was driven lower by the completion of a share offering in mid-September. It was a smart move financially, as it nearly doubled the amount of cash on the balance sheet from the end of June, but the $230 million in gross proceeds also increased the number of shares outstanding by 10%. Dilution isn't the only thing on the minds of investors.

So what

While the leading CRISPR companies are flush with cash, they're all going to need strong balance sheets to conduct global clinical trials. So although share dilution stings, raising large sums of money -- and quickly via share offerings -- is a necessary part of being a development-stage biopharma.

CRISPR Therapeutics will be the first to put its war chest to use in the clinic. The company and its partner Vertex Pharmaceuticals recently began clinical trials in Europe for their lead drug candidate, CTX001, as a treatment for the blood disorder beta-thalassemia. That will be followed soon by clinical trials in the United States investigating the drug candidate's potential to treat sickle cell disease (another blood disorder), which may now proceed after the U.S. Food and Drug Administration lifted a clinical hold on the therapy.

Now what

While investors have been awaiting the day that CRISPR-based drug candidates enter clinical trials in the United States, the news was received with relatively mild movement in the stock price -- and certainly not enough to erase the recent slide. That's likely because the announcement was largely expected. And because investors know that the now-$1.8 billion company has a long road ahead of it.

10 stocks we like better than CRISPR TherapeuticsWhen investing geniuses David and Tom Gardner have a stock tip, it can pay to listen. After all, the newsletter they have run for over a decade, Motley Fool Stock Advisor, has quadrupled the market.*

David and Tom just revealed what they believe are the 10 best stocks for investors to buy right now... and CRISPR Therapeutics wasn't one of them! That's right -- they think these 10 stocks are even better buys.

Click here to learn about these picks!

*Stock Advisor returns as of August 6, 2018

Maxx Chatsko has no position in any of the stocks mentioned. The Motley Fool owns shares of CRISPR Therapeutics. The Motley Fool recommends Vertex Pharmaceuticals. The Motley Fool has a disclosure policy.