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Baxter International

Baxter's Potential Alzheimer's Treatment Immunoglobulin Misses Primary Endpoints

Baxter International Inc. (BAX) said results from a late-stage study of its potential treatment for Alzheimer's, immunoglobulin, were negative.The results didn't meet the co-primary endpoints of reducing cognitive decline and preserving functional abilities in patients with mild to moderate Alzheimer's disease.Baxter--which makes medical products for people with bleeding, kidney and immune disorders, among other conditions--said it will reconsider its current approach for its Alzheimer's program and will determine next steps after full data analyses. Current Baxter studies of immunoglobulin in mild to moderate Alzheimer's disease will be discontinued.Top-line analyses from the randomized, double-blind, placebo-controlled, multicenter trial found that after 18 months of treatment, patients with mild to moderate Alzheimer's disease taking Baxter's immunoglobulin treatment didn't demonstrate a statistically significant difference in the rate of cognitive decline as compared with placebo. ...

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