SAN MATEO, California, Oct 29, 2008 (PR Newswire Europe via COMTEX) ----NeurogesX, Inc. (Nasdaq: NGSX), a biopharmaceutical company focused on developing and commercializing novel pain management therapies, today announced it will report results for its third quarter 2008 on Thursday, November 6, 2008, after the market closes.

A conference call to review the results and discuss corporate and clinical initiatives for the remainder of 2008 and into 2009 will begin at 4:30 p.m. ET (1:30 p.m. PT) on November 6, 2008 and will be hosted by Anthony DiTonno, President and Chief Executive Officer, and Stephen Ghiglieri, Chief Financial Officer.

To participate in the conference call, please dial +1-877-407-0789 (USA) or +1-201-689-8562 (International). In addition, a dial-up replay of the conference call will be available beginning November 6, 2008 at 8:00 p.m. ET (5:00 p.m. PT) and ending on November 16, 2008. The replay telephone number is +1-877-660-6853 (USA) or +1-201-612-7415 (International), Account Number: 3055, Conference ID Number: 301804.

A live web cast of the call will also be available from the Investor Relations section on the corporate web site at http://www.neurogesx.com. A web cast replay can be accessed on the corporate web site beginning November 6, 2008 at the same time as the conference call and will remain on the site for one month ending December 6, 2008.

About NeurogesX, Inc.

NeurogesX (Nasdaq: NGSX) is a biopharmaceutical company focused on developing and commercializing novel pain management therapies. Its initial focus is on chronic peripheral neuropathic pain, including postherpetic neuralgia (PHN), painful HIV-distal sensory polyneuropathy (HIV-DSP) and painful diabetic neuropathy (PDN). NeurogesX' late stage product portfolio is led by its product candidate NGX-4010, a dermal patch designed to manage pain associated with peripheral neuropathic pain conditions, that the Company believes offers significant advantages over other pain therapies. NeurogesX submitted a new drug application (NDA) for NGX-4010 with the U.S. Food and Drug Administration (FDA) in October 2008 for PHN, which is subject to acceptance by the FDA. Additionally, a marketing authorization application (MAA) for NGX-4010 seeking approval for peripheral neuropathic pain is currently under review by the European Medicines Agency (EMEA). NeurogesX' second most advanced product candidate, NGX-1998, is a topically applied, liquid formulation containing a high concentration of capsaicin designed to treat pain associated with neuropathic pain conditions. NGX-1998 is currently in a Phase 1 clinical trial. The objective of the development program for NGX-1998 is to determine its ability to provide protracted pain relief from a single treatment. As a liquid, NGX-1998 is expected to be suitable for areas of the skin where dermal patches may be difficult or impractical to apply, such as the hairline. NGX-1998 is being developed with the goal of it becoming a product that has the potential to be used by a broad spectrum of the physician population. NGX-1998 was previously studied in two Phase 1 studies in healthy volunteers conducted under an exploratory investigational new drug application.

Safe Harbor Statement

This press release contains forward-looking statements for purposes of the Private Securities Litigation Reform Act of 1995 (the "Act"). NeurogesX disclaims any intent or obligation to update these forward-looking statements, and claims the protection of the Safe Harbor for forward-looking statements contained in the Act. Examples of such statements include, but are not limited to, possible approval of NeurogesX' product candidates by the FDA or EMEA, the potential markets for NeurogesX' product candidates and the expected benefits of NeurogesX' product candidates; the suitability of NGX-1998 for certain treatments and potential usage by broader physician populations. Such statements are based on management's current expectations, but actual results may differ materially due to various risks and uncertainties, including, but not limited to, NeurogesX' product candidates may have unexpected adverse side effects or inadequate therapeutic efficacy; positive results in clinical trials may not be sufficient to obtain FDA or European regulatory approval; any regulatory approvals which are received may be limited to certain indications; physician or patient reluctance to use NGX-4010 or NGX-1998, if approved, or the inability of physicians to obtain sufficient reimbursement for such procedures; potential alternative therapies; maintaining adequate patent or trade secret protection without violating the intellectual property rights of others; and other difficulties or delays in, clinical development, obtaining regulatory approval, market acceptance and commercialization of NeurogesX' product candidates and the advantages of NeurogesX' product candidates over other pain therapies. For further information regarding these and other risks related to NeurogesX' business, investors should consult NeurogesX' filings with the Securities and Exchange Commission.

NeurogesX, Inc.
   Stephen Ghiglieri
   Chief Financial Officer
   +1-650-358-3310
   
   The Ruth Group
   Stephanie Carrington / Sara Ephraim (investors)
   +1-646-536-7017 / 7002
   scarrington@theruthgroup.com
   sephraim@theruthgroup.com
   
   Jason Rando (media)
   +1-646-536-7025
   jrando@theruthgroup.com
   

Web site: http://www.neurogesx.com

Stephen Ghiglieri, +1-650-358-3310, Chief Financial Officer of NeurogesX, Inc.;
   Investors, Stephanie Carrington, or Sara Ephraim, +1-646-536-7017,
   +1-646-536-7002, scarrington@theruthgroup.com, sephraim@theruthgroup.com, both
   of The Ruth Group for NeurogesX, Inc.; Media, Jason Rando, +1-646-536-7025,
   jrando@theruthgroup.com, for NeurogesX, Inc.
   

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