JPMorgan, Telsa, GameStop, General Motors and Ziopharm are big market movers

Stocks that moved substantially or traded heavily Wednesday on the New York Stock Exchange and the Nasdaq Stock Market:

NYSE

JPMorgan Chase & Co., down $2.03 to $56.81

The bank reported a 7 percent drop in fourth-quarter profit partly because of legal expenses, falling short of expectations.

GameStop Corp., up $3.44 to $36.21

The video game retailer reported a boost in sales during the holiday period and expects strong demand into the first quarter.

Freeport-McMoRan Inc., down $2.30 to $18.74

The mineral and energy mining company's stock fell as copper prices dropped to their lowest point in more than five years.

General Motors Co., down 95 cents to $34.30

The auto company said it expects pretax profit to rise this year and predicted improved automotive results.

St. Jude Medical Inc., up $1.77 to $67.56

The medical device maker reported preliminary revenue figures in line with its prior guidance and reaffirmed its profit outlook.

Nasdaq

Ziopharm Oncology Inc., up $3.13 to $8.87

The biotech company entered a licensing deal with The University of Texas MD Anderson Center for potential cancer treatments.

Tesla Motors Inc., down $11.56 to $192.69

The electric auto company's CEO, Elon Musk, told an auto industry gathering that the company will not be profitable until 2020.

Linear Technology Corp., up 45 cents to $45.62

The circuit maker reported better-than-expected fiscal second-quarter profit, though its revenue fell short of forecasts.