Novartis, Exelixis, Cloud Peak Energy, Conns, and Norwegian Cruise are big market movers

Industries Associated Press

Stocks that moved substantially or traded heavily Tuesday on the New York Stock Exchange and the Nasdaq Stock Market:

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NYSE

Novartis AG, up $3.43 to $93.47

The drug developer presented positive data for a potential heart-failure drug and will ask for approval by the end of the year.

Las Vegas Sands Corp., down $3.41 to $63.10

The casino operator and its gambling company peers experienced a decline in revenue from the gambling hub Macau during August.

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Cloud Peak Energy Inc., down $1.27 to $14.44

The coal company lowered its coal shipment and adjusted earnings guidance for 2014, citing rail issues and weather impacts.

Crown Holdings Inc., up $1.85 to $50.12

The packaging products company is buying the Mexican can packaging business of brewer Heineken for just under $1.23 billion.

Nasdaq

Exelixis Inc., down $2.29 to $1.85

The biotechnology company said its potential treatment for prostate cancer failed to meet a key goal in a late-stage study.

Conns Inc., down $13.83 to $31

The consumer goods retailer reported second-quarter profit below Wall Street expectations and cut its full-year profit guidance.

Norwegian Cruise Line Holdings Ltd., up $3.68 to $36.99

The cruise line will buy Prestige Cruises International for about $3 billion and expects to close the deal in the fourth quarter.

Acadia Pharmaceuticals Inc., up $2.63 to $26.61

The biotechnology company received a special FDA designation for its potential Parkinson's disease psychosis treatment, Nuplazid.