Shire plc Shire Plc : Director/Pdmr Shareholding -2-

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Director/PDMR Shareholding

November 1, 2017

- Shire plc (LSE: SHP, NASDAQ: SHPG)

Notification of transactions by persons discharging managerial

responsibilities

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1. Details of the person discharging managerial responsibilities

("PDMR") / person closely associated with them ("PCA")

a) Name Flemming Ornskov

2. Reason for the notification

a) Position / status Chief Executive Officer - PDMR

b) Initial notification / Initial notification

amendment

3. Details of the issuer, emission allowance participant,

auction platform, auctioneer or auction monitor

a) Name Shire plc

b) LEI 54930005LQRLI2UXRQ59

4. Details of the transaction(s): section to be repeated

for (i) each type of instrument; (ii) each type of

transaction; (iii) each date; and (iv) each place

where transactions have been conducted

a) Description of the Shire plc American Depositary Shares ("ADSs")

financial instrument,

type of instrument

Identification code ISIN: US82481R1068

b) Nature of the Receipt of option over notional ADSs granted under

transaction the Shire Global Employee Stock Purchase Plan. Dr.

Ornskov has elected to save $480.76 per fortnight.

The option price will be the lower of 85% of the fair

market value of an ADS on October 31, 2017, and 85%

of the fair market value of an ADS on October 30,

2018.

c) Price(s) and volume(s) Price(s) Volume(s)

N/A N/A

d) Aggregated information N/A (single transaction)

- Aggregated volume

- Price

e) Date of the November 1, 2017

transaction

f) Place of the N/A

transaction

1. Details of the person discharging managerial responsibilities

("PDMR") / person closely associated with them ("PCA")

a) Name Joanne Cordeiro

2. Reason for the notification

a) Position / status Chief Human Resources Officer - PDMR

b) Initial notification / Initial notification

amendment

3. Details of the issuer, emission allowance participant,

auction platform, auctioneer or auction monitor

a) Name Shire plc

b) LEI 54930005LQRLI2UXRQ59

4. Details of the transaction(s): section to be repeated

for (i) each type of instrument; (ii) each type of

transaction; (iii) each date; and (iv) each place

where transactions have been conducted

a) Description of the Shire plc American Depositary Shares ("ADSs")

financial instrument,

type of instrument

Identification code ISIN: US82481R1068

b) Nature of the Receipt of option over notional ADSs granted under

transaction the Shire Global Employee Stock Purchase Plan. Ms.

Cordeiro has elected to save $480.76 per fortnight.

The option price will be the lower of 85% of the fair

market value of an ADS on October 31, 2017, and 85%

of the fair market value of an ADS on October 30,

2018.

c) Price(s) and volume(s) Price(s) Volume(s)

N/A N/A

d) Aggregated information N/A (single transaction)

- Aggregated volume

- Price

e) Date of the November 1, 2017

transaction

f) Place of the N/A

transaction

1. Details of the person discharging managerial responsibilities

("PDMR") / person closely associated with them ("PCA")

a) Name Bill Mordan

2. Reason for the notification

a) Position / status General Counsel and Company Secretary - PDMR

b) Initial notification / Initial notification

amendment

3. Details of the issuer, emission allowance participant,

auction platform, auctioneer or auction monitor

a) Name Shire plc

b) LEI 54930005LQRLI2UXRQ59

4. Details of the transaction(s): section to be repeated

for (i) each type of instrument; (ii) each type of

transaction; (iii) each date; and (iv) each place

where transactions have been conducted

a) Description of the Shire plc American Depositary Shares ("ADSs")

financial instrument,

type of instrument

Identification code ISIN: US82481R1068

b) Nature of the Receipt of option over notional ADSs granted under

transaction the Shire Global Employee Stock Purchase Plan. Mr.

Mordan has elected to save $480.76 per fortnight.

The option price will be the lower of 85% of the fair

market value of an ADS on October 31, 2017, and 85%

of the fair market value of an ADS on October 30,

2018.

c) Price(s) and volume(s) Price(s) Volume(s)

N/A N/A

d) Aggregated information N/A (single transaction)

- Aggregated volume

- Price

e) Date of the November 1, 2017

transaction

f) Place of the N/A

transaction

1. Details of the person discharging managerial responsibilities

("PDMR") / person closely associated with them ("PCA")

a) Name Perry Sternberg

2. Reason for the notification

a) Position / status Head of US Commercial - PDMR

b) Initial notification / Initial notification

amendment

3. Details of the issuer, emission allowance participant,

auction platform, auctioneer or auction monitor

a) Name Shire plc

b) LEI 54930005LQRLI2UXRQ59

4. Details of the transaction(s): section to be repeated

for (i) each type of instrument; (ii) each type of

transaction; (iii) each date; and (iv) each place

where transactions have been conducted

a) Description of the Shire plc American Depositary Shares ("ADSs")

financial instrument,

type of instrument

Identification code ISIN: US82481R1068

b) Nature of the Receipt of option over notional ADSs granted under

transaction the Shire Global Employee Stock Purchase Plan. Mr.

Sternberg has elected to save $480.76 per fortnight.

The option price will be the lower of 85% of the fair

market value of an ADS on October 31, 2017, and 85%

of the fair market value of an ADS on October 30,

2018.

c) Price(s) and volume(s) Price(s) Volume(s)

N/A N/A

d) Aggregated information N/A (single transaction)

- Aggregated volume

- Price

e) Date of the November 1, 2017

transaction

f) Place of the N/A

transaction

1. Details of the person discharging managerial responsibilities

("PDMR") / person closely associated with them ("PCA")

a) Name Kim Stratton

2. Reason for the notification

a) Position / status Head of International Commercial - PDMR

b) Initial notification / Initial notification

amendment

3. Details of the issuer, emission allowance participant,

auction platform, auctioneer or auction monitor

a) Name Shire plc

b) LEI 54930005LQRLI2UXRQ59

4. Details of the transaction(s): section to be repeated

for (i) each type of instrument; (ii) each type of

transaction; (iii) each date; and (iv) each place

where transactions have been conducted

a) Description of the Shire plc Ordinary Shares of 5 pence each ("Ordinary

financial instrument, Shares")

type of instrument

Identification code ISIN: JE00B2QKY057

b) Nature of the Receipt of option over notional Ordinary Shares granted

transaction under the Shire Global Employee Stock Purchase Plan.

Ms. Stratton has elected to save Fr.1,007.25 per month.

The option price will be the lower of 85% of the fair

market value of an Ordinary Share on October 31, 2017,

and 85% of the fair market value of an Ordinary Share

on October 30, 2018.

c) Price(s) and volume(s) Price(s) Volume(s)

N/A N/A

d) Aggregated information N/A (single transaction)

- Aggregated volume

- Price

e) Date of the November 1, 2017

transaction

f) Place of the N/A

transaction

1. Details of the person discharging managerial responsibilities

("PDMR") / person closely associated with them ("PCA")

a) Name Matt Walker

2. Reason for the notification

a) Position / status Head of Technical Operations - PDMR

b) Initial notification / Initial notification

amendment

3. Details of the issuer, emission allowance participant,

auction platform, auctioneer or auction monitor

a) Name Shire plc

b) LEI 54930005LQRLI2UXRQ59

4. Details of the transaction(s): section to be repeated

for (i) each type of instrument; (ii) each type of

transaction; (iii) each date; and (iv) each place

where transactions have been conducted

a) Description of the Shire plc American Depositary Shares ("ADSs")

financial instrument,

type of instrument

Identification code ISIN: US82481R1068

b) Nature of the Receipt of option over notional ADSs granted under

transaction the Shire Global Employee Stock Purchase Plan. Mr.

Walker has elected to save $480.76 per fortnight.

The option price will be the lower of 85% of the fair

market value of an ADS on October 31, 2017, and 85%

of the fair market value of an ADS on October 30,

2018.

c) Price(s) and volume(s) Price(s) Volume(s)

N/A N/A

d) Aggregated information N/A (single transaction)

- Aggregated volume

- Price

e) Date of the November 1, 2017

transaction

f) Place of the N/A

transaction

Oliver Strawbridge

Senior Assistant Company Secretary

For further information please contact:

Investor Relations

Ian Karp ikarp@shire.com +1 781 482 9018

Robert Coates rcoates@shire.com +44 203 549 0874

Media

Lisa Adler lisa.adler@shire.com +1 617 588 8607

Katie Joyce kjoyce@shire.com +1 781 482 2779

NOTES TO EDITORS

About Shire

Shire is the global leader in serving patients with rare diseases. We

strive to develop best-in-class therapies across a core of rare disease

areas including hematology, immunology, genetic diseases, neuroscience,

and internal medicine with growing therapeutic areas in ophthalmics and

oncology. Our diversified capabilities enable us to reach patients in

more than 100 countries who are struggling to live their lives to the

fullest.

We feel a strong sense of urgency to address unmet medical needs and

work tirelessly to improve people's lives with medicines that have a

meaningful impact on patients and all who support them on their journey.

www.shire.com

This announcement is distributed by Nasdaq Corporate Solutions on behalf

of Nasdaq Corporate Solutions clients.

The issuer of this announcement warrants that they are solely

responsible for the content, accuracy and originality of the information

contained therein.

Source: Shire plc via Globenewswire

(END) Dow Jones Newswires

November 01, 2017 11:15 ET (15:15 GMT)