Shire plc Shire Plc : Total Voting Rights

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Total Voting Rights

October 2, 2017 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company"), in

accordance with 5.6.1R of the Financial Conduct Authority's (the "FCA")

Disclosure Guidance and Transparency Rules, notifies the market of the

following:

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As at September 30, 2017, the Company's issued ordinary share capital

comprised 908,509,840 ordinary shares of 5 pence each with voting rights

and a further 7,357,283 ordinary shares held in treasury.

Therefore, the total number of voting rights in the Company is

908,509,840. This is the figure which should be used by shareholders as

the denominator for the calculations by which they will determine if

they are required to notify their interest in, or a change to their

interest in, the Company under the FCA's Disclosure Guidance and

Transparency Rules.

Sarah Rixon

Company Secretarial Assistant

For further information please contact:

Investor Relations

Ian Karp ikarp@shire.com +1 781 482 9018

Robert Coates rcoates@shire.com +44 1256 894874

Media

Lisa Adler lisa.adler@shire.com +1 617 588 8607

NOTES TO EDITORS

About Shire

Shire is the leading global biotechnology company focused on serving

people with rare diseases. We strive to develop best-in-class products,

many of which are available in more than 100 countries, across core

therapeutic areas including Hematology, Immunology, Neuroscience,

Ophthalmics, Lysosomal Storage Disorders, Gastrointestinal / Internal

Medicine / Endocrine and Hereditary Angioedema; and a growing franchise

in Oncology.

Our employees come to work every day with a shared mission: to develop

and deliver breakthrough therapies for the hundreds of millions of

people in the world affected by rare diseases and other high-need

conditions, and who lack effective therapies to live their lives to the

fullest.

www.shire.com

This announcement is distributed by Nasdaq Corporate Solutions on behalf

of Nasdaq Corporate Solutions clients.

The issuer of this announcement warrants that they are solely

responsible for the content, accuracy and originality of the information

contained therein.

Source: Shire plc via Globenewswire

(END) Dow Jones Newswires

October 02, 2017 09:15 ET (13:15 GMT)