Shire plc Shire Plc : Director/Pdmr Shareholding -3-

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Director/PDMR Shareholding

July 3, 2017

- Shire plc (LSE: SHP, NASDAQ: SHPG)

Notification of transactions by persons discharging managerial

responsibilities

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Details of the person discharging managerial responsibilities

1. ("PDMR") / person closely associated with them ("PCA")

a) Name Susan Kilsby

2. Reason for the notification

a) Position / status Chairman - PDMR

Initial notification /

b) amendment Initial notification

Details of the issuer, emission allowance participant,

3. auction platform, auctioneer or auction monitor

a) Name Shire plc

b) LEI 54930005LQRLI2UXRQ59

Details of the transaction(s): section to be repeated

for (i) each type of instrument; (ii) each type of

transaction; (iii) each date; and (iv) each place

4. where transactions have been conducted

Description of the financial

instrument, type of

a) instrument Shire plc American Depositary Shares ("ADSs")

Identification code ISIN: US82481R1068

Acquisition of ADSs, being the part of Ms. Kilsby's

total fees that are paid in ADSs for the period of

b) Nature of the transaction service from April 1 to June 30, 2017.

c) Price(s) and volume(s) Price(s) Volume(s)

See appendix below

Aggregated information

- Aggregated volume

d) - Price Weighted average price Volume

$164.4008 162

e) Date of the transaction June 30, 2017

f) Place of the transaction XNAS / ARCX

Details of the person discharging managerial responsibilities

1. ("PDMR") / person closely associated with them ("PCA")

a) Name William Burns

2. Reason for the notification

a) Position / status Senior Independent Director - PDMR

Initial notification /

b) amendment Initial notification

Details of the issuer, emission allowance participant,

3. auction platform, auctioneer or auction monitor

a) Name Shire plc

b) LEI 54930005LQRLI2UXRQ59

Details of the transaction(s): section to be repeated

for (i) each type of instrument; (ii) each type of

transaction; (iii) each date; and (iv) each place

4. where transactions have been conducted

Description of the

financial instrument, type Shire plc Ordinary Shares of 5 pence each ("Ordinary

a) of instrument Shares")

Identification code ISIN: JE00B2QKY057

Acquisition of Ordinary Shares, being the part of

Mr. Burns' total fees that are paid in Ordinary Shares

for the period of service from April 1 to June 30,

b) Nature of the transaction 2017.

c) Price(s) and volume(s) Price(s) Volume(s)

See appendix below

Aggregated information

- Aggregated volume

d) - Price Weighted average price Volume

GBP42.5500 156

e) Date of the transaction June 30, 2017

f) Place of the transaction XLON / BATE

Details of the person discharging managerial responsibilities

1. ("PDMR") / person closely associated with them ("PCA")

a) Name Dominic Blakemore

2. Reason for the notification

a) Position / status Non-Executive Director - PDMR

Initial notification /

b) amendment Initial notification

Details of the issuer, emission allowance participant,

3. auction platform, auctioneer or auction monitor

a) Name Shire plc

b) LEI 54930005LQRLI2UXRQ59

Details of the transaction(s): section to be repeated

for (i) each type of instrument; (ii) each type of

transaction; (iii) each date; and (iv) each place

4. where transactions have been conducted

Description of the

financial instrument, type Shire plc Ordinary Shares of 5 pence each ("Ordinary

a) of instrument Shares")

Identification code ISIN: JE00B2QKY057

Acquisition of Ordinary Shares, being the part of

Mr. Blakemore's total fees that are paid in Ordinary

Shares for the period of service from April 1 to June

b) Nature of the transaction 30, 2017.

c) Price(s) and volume(s) Price(s) Volume(s)

See appendix below

Aggregated information

- Aggregated volume

d) - Price Weighted average price Volume

GBP42.5500 152

e) Date of the transaction June 30, 2017

f) Place of the transaction XLON / BATE

Details of the person discharging managerial responsibilities

1. ("PDMR") / person closely associated with them ("PCA")

a) Name Olivier Bohuon

2. Reason for the notification

a) Position / status Non-Executive Director - PDMR

Initial notification /

b) amendment Initial notification

Details of the issuer, emission allowance participant,

3. auction platform, auctioneer or auction monitor

a) Name Shire plc

b) LEI 54930005LQRLI2UXRQ59

Details of the transaction(s): section to be repeated

for (i) each type of instrument; (ii) each type of

transaction; (iii) each date; and (iv) each place

4. where transactions have been conducted

Description of the

financial instrument, type Shire plc Ordinary Shares of 5 pence each ("Ordinary

a) of instrument Shares")

Identification code ISIN: JE00B2QKY057

Acquisition of Ordinary Shares, being the part of

Mr. Bohuon's total fees that are paid in Ordinary

Shares for the period of service from April 1 to June

b) Nature of the transaction 30, 2017.

c) Price(s) and volume(s) Price(s) Volume(s)

See appendix below

Aggregated information

- Aggregated volume

d) - Price Weighted average price Volume

GBP42.5500 136

e) Date of the transaction June 30, 2017

f) Place of the transaction XLON / BATE

Details of the person discharging managerial responsibilities

1. ("PDMR") / person closely associated with them ("PCA")

a) Name Ian Clark

2. Reason for the notification

a) Position / status Non-Executive Director - PDMR

Initial notification /

b) amendment Initial notification

Details of the issuer, emission allowance participant,

3. auction platform, auctioneer or auction monitor

a) Name Shire plc

b) LEI 54930005LQRLI2UXRQ59

Details of the transaction(s): section to be repeated

for (i) each type of instrument; (ii) each type of

transaction; (iii) each date; and (iv) each place

4. where transactions have been conducted

Description of the financial

instrument, type of

a) instrument Shire plc American Depositary Shares ("ADSs")

Identification code ISIN: US82481R1068

Acquisition of ADSs, being the part of Mr. Clark's

total fees that are paid in ADSs for the period of

b) Nature of the transaction service from April 1 to June 30, 2017.

c) Price(s) and volume(s) Price(s) Volume(s)

See appendix below

Aggregated information

- Aggregated volume

d) - Price Weighted average price Volume

$164.4008 42

e) Date of the transaction June 30, 2017

f) Place of the transaction XNAS / ARCX

Details of the person discharging managerial responsibilities

1. ("PDMR") / person closely associated with them ("PCA")

a) Name Gail Fosler

2. Reason for the notification

a) Position / status Non-Executive Director - PDMR

Initial notification /

b) amendment Initial notification

Details of the issuer, emission allowance participant,

3. auction platform, auctioneer or auction monitor

a) Name Shire plc

b) LEI 54930005LQRLI2UXRQ59

Details of the transaction(s): section to be repeated

for (i) each type of instrument; (ii) each type of

transaction; (iii) each date; and (iv) each place

4. where transactions have been conducted

Description of the financial

instrument, type of

a) instrument Shire plc American Depositary Shares ("ADSs")

Identification code ISIN: US82481R1068

Acquisition of ADSs, being the part of Ms. Fosler's

total fees that are paid in ADSs for the period of

b) Nature of the transaction service from April 1 to June 30, 2017.

c) Price(s) and volume(s) Price(s) Volume(s)

See appendix below

Aggregated information

- Aggregated volume

d) - Price Weighted average price Volume

$164.4008 44

e) Date of the transaction June 30, 2017

f) Place of the transaction XNAS / ARCX

Details of the person discharging managerial responsibilities

1. ("PDMR") / person closely associated with them ("PCA")

a) Name Steven Gillis

2. Reason for the notification

a) Position / status Non-Executive Director - PDMR

Initial notification /

b) amendment Initial notification

Details of the issuer, emission allowance participant,

3. auction platform, auctioneer or auction monitor

a) Name Shire plc

b) LEI 54930005LQRLI2UXRQ59

Details of the transaction(s): section to be repeated

for (i) each type of instrument; (ii) each type of

transaction; (iii) each date; and (iv) each place

4. where transactions have been conducted

Description of the financial

instrument, type of

a) instrument Shire plc American Depositary Shares ("ADSs")

Identification code ISIN: US82481R1068

Acquisition of ADSs, being the part of Dr. Gillis'

total fees that are paid in ADSs for the period of

b) Nature of the transaction service from April 1 to June 30, 2017.

c) Price(s) and volume(s) Price(s) Volume(s)

See appendix below

Aggregated information

- Aggregated volume

d) - Price Weighted average price Volume

$164.4008 47

e) Date of the transaction June 30, 2017

f) Place of the transaction XNAS / ARCX

Details of the person discharging managerial responsibilities

1. ("PDMR") / person closely associated with them ("PCA")

a) Name David Ginsburg

2. Reason for the notification

a) Position / status Non-Executive Director - PDMR

Initial notification /

b) amendment Initial notification

Details of the issuer, emission allowance participant,

3. auction platform, auctioneer or auction monitor

a) Name Shire plc

b) LEI 54930005LQRLI2UXRQ59

Details of the transaction(s): section to be repeated

for (i) each type of instrument; (ii) each type of

transaction; (iii) each date; and (iv) each place

4. where transactions have been conducted

Description of the

financial instrument, type

a) of instrument Shire plc American Depositary Shares ("ADSs")

Identification code ISIN: US82481R1068

Acquisition of ADSs, being the part of Dr. Ginsburg's

total fees that are paid in ADSs for the period of

b) Nature of the transaction service from April 1 to June 30, 2017.

c) Price(s) and volume(s) Price(s) Volume(s)

See appendix below

Aggregated information

- Aggregated volume

d) - Price Weighted average price Volume

$164.4008 48

e) Date of the transaction June 30, 2017

f) Place of the transaction XNAS / ARCX

Details of the person discharging managerial responsibilities

1. ("PDMR") / person closely associated with them ("PCA")

a) Name Sara Mathew

2. Reason for the notification

a) Position / status Non-Executive Director - PDMR

Initial notification /

b) amendment Initial notification

Details of the issuer, emission allowance participant,

3. auction platform, auctioneer or auction monitor

a) Name Shire plc

b) LEI 54930005LQRLI2UXRQ59

Details of the transaction(s): section to be repeated

for (i) each type of instrument; (ii) each type of

transaction; (iii) each date; and (iv) each place

4. where transactions have been conducted

Description of the financial

instrument, type of

a) instrument Shire plc American Depositary Shares ("ADSs")

Identification code ISIN: US82481R1068

Acquisition of ADSs, being the part of Ms. Mathew's

total fees that are paid in ADSs for the period of

b) Nature of the transaction service from April 1 to June 30, 2017.

c) Price(s) and volume(s) Price(s) Volume(s)

See appendix below

Aggregated information

- Aggregated volume

d) - Price Weighted average price Volume

$164.4008 46

e) Date of the transaction June 30, 2017

f) Place of the transaction XNAS / ARCX

Details of the person discharging managerial responsibilities

1. ("PDMR") / person closely associated with them ("PCA")

a) Name Anne Minto

2. Reason for the notification

a) Position / status Non-Executive Director - PDMR

Initial notification /

b) amendment Initial notification

Details of the issuer, emission allowance participant,

3. auction platform, auctioneer or auction monitor

a) Name Shire plc

b) LEI 54930005LQRLI2UXRQ59

Details of the transaction(s): section to be repeated

for (i) each type of instrument; (ii) each type of

transaction; (iii) each date; and (iv) each place

4. where transactions have been conducted

Description of the

financial instrument, type Shire plc Ordinary Shares of 5 pence each ("Ordinary

a) of instrument Shares")

Identification code ISIN: JE00B2QKY057

Acquisition of Ordinary Shares, being the part of

Ms. Minto's total fees that are paid in Ordinary Shares

for the period of service from April 1 to June 30,

b) Nature of the transaction 2017.

c) Price(s) and volume(s) Price(s) Volume(s)

See appendix below

Aggregated information

- Aggregated volume

d) - Price Weighted average price Volume

GBP42.5500 153

e) Date of the transaction June 30, 2017

f) Place of the transaction XLON / BATE

Details of the person discharging managerial responsibilities

1. ("PDMR") / person closely associated with them ("PCA")

a) Name Albert Stroucken

2. Reason for the notification

a) Position / status Non-Executive Director - PDMR

Initial notification /

b) amendment Initial notification

Details of the issuer, emission allowance participant,

3. auction platform, auctioneer or auction monitor

a) Name Shire plc

b) LEI 54930005LQRLI2UXRQ59

Details of the transaction(s): section to be repeated

for (i) each type of instrument; (ii) each type of

transaction; (iii) each date; and (iv) each place

4. where transactions have been conducted

Description of the

financial instrument, type

a) of instrument Shire plc American Depositary Shares ("ADSs")

Identification code ISIN: US82481R1068

Acquisition of ADSs, being the part of Mr. Stroucken's

total fees that are paid in ADSs for the period of

b) Nature of the transaction service from April 1 to June 30, 2017.

c) Price(s) and volume(s) Price(s) Volume(s)

See appendix below

Aggregated information

- Aggregated volume

d) - Price Weighted average price Volume

$164.4008 48

e) Date of the transaction June 30, 2017

f) Place of the transaction XNAS / ARCX

Appendix: individual / aggregated transaction details for PDMRs

Shire plc American Depositary Shares

Place of the transaction Price(s) Volume(s)

ARCX $164.3900 100

XNAS $164.3900 100

XNAS $164.4100 37

XNAS $164.4100 200

Place of the transaction Weighted average price Aggregated volume

ARCX $164.3900 100

XNAS $164.4041 337

Total $164.4008 437

Shire plc Ordinary Shares of 5 pence each

Place of the transaction Price(s) Volume(s)

XLON GBP42.5500 117

XLON GBP42.5500 70

XLON GBP42.5500 58

XLON GBP42.5500 46

XLON GBP42.5500 49

XLON GBP42.5500 150

XLON GBP42.5500 11

BATE GBP42.5500 96

Place of the transaction Weighted average price Aggregated volume

XLON GBP42.5500 501

BATE GBP42.5500 96

Total GBP42.5500 597

Oliver Strawbridge

Senior Assistant Company Secretary

For further information please contact:

Investor Relations

Ian Karp ikarp@shire.com +1 781 482 9018

Robert Coates rcoates@shire.com +44 1256 894874

Media

Lisa Adler lisa.adler@shire.com +1 617 588 8607

Debbi Ford debbi.ford@shire.com +1 617 949 9083

NOTES TO EDITORS

About Shire

Shire is the leading global biotechnology company focused on serving

people with rare diseases. We strive to develop best-in-class products,

many of which are available in more than 100 countries, across core

therapeutic areas including Hematology, Immunology, Neuroscience,

Ophthalmics, Lysosomal Storage Disorders, Gastrointestinal / Internal

Medicine / Endocrine and Hereditary Angioedema; and a growing franchise

in Oncology.

Our employees come to work every day with a shared mission: to develop

and deliver breakthrough therapies for the hundreds of millions of

people in the world affected by rare diseases and other high-need

conditions, and who lack effective therapies to live their lives to the

fullest.

www.shire.com

This announcement is distributed by Nasdaq Corporate Solutions on behalf

of Nasdaq Corporate Solutions clients.

The issuer of this announcement warrants that they are solely

responsible for the content, accuracy and originality of the information

contained therein.

Source: Shire plc via Globenewswire

(END) Dow Jones Newswires

July 03, 2017 08:45 ET (12:45 GMT)