Medtronic Inc said a U.S. jury ruled that its heart valve implant infringed a patent held by Edward Lifesciences Corp and awarded Edwards $392.5 million in damages.
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Medtronic said it would appeal the ruling made by a jury in the Federal District Court of Delaware.
The medical device maker said it would oppose any request for an injunction by Edwards.
Medtronic said it expected U.S. approval for the CoreValve heart implant system by the end of 2014.
Edwards shares rose as much as 4 percent to $73.42 on Wednesday on the New York Stock Exchange. Medtronic shares were up slightly at $59.64.